4-Bromopiperidine hydrobromide

Base Information

• Chemical Name: 4-Bromopiperidine hydrobromide
• CAS No.: 54288-70-9
• Molecular Formula: C5H10BrN^.HBr
• Molecular Weight: 244.957
• Hs Code.: 29333990
• European Community (EC) Number: 628-285-2
• DSSTox Substance ID: DTXSID90370441
• Mol file: 54288-70-9.mol

Synonyms:4-Bromopiperidine hydrobromide;54288-70-9;4-BromopiperidineHBr;4-Bromopiperidine HBr;Piperidine, 4-bromo-, hydrobromide;4-bromopiperidine;hydrobromide;MFCD00191858;4-Bromopiperidine hydrobromide (1:1);4-Bromopiperidinehydrobromide;4-Bromo-piperidine hydrobromide;SCHEMBL1691767;DTXSID90370441;LVTIZXGNLIKUQZ-UHFFFAOYSA-N;4-bromopiperidine hydrobromide salt;4-Bromopiperidine hydrobromide, 98%;CL3102;GEO-00559;AKOS005254532;CS-W014130;SB43137;AC-23243;AS-17553;SY013399;AM20100339;B3830;FT-0617920;4-BROMOPIPERIDINEHBR;A19744;EN300-142176

Chemical Property of 4-Bromopiperidine hydrobromide

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 199-202 °C(lit.)
• Boiling Point: 182.3oC at 760 mmHg
• Flash Point: 64.1oC
• PSA: 12.03000
• LogP: 2.42020
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 244.92378
• Heavy Atom Count: 8
• Complexity: 50

Purity/Quality:

99% ^*data from raw suppliers

4-Bromopiperidine hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CNCCC1Br.Br
• Description: 4-Bromopiperidine hydrobromide is a salt of halogenopiperidine. Synthesis of tritium labelled N-aminopiperidine using 4-bromopiperidine as precursor has been reported.
• Uses: 4-Bromopiperidine hydrobromide is a useful research chemical. 4-Bromopiperidine hydrobromide may be used as a starting material in the synthesis of [2H] piperidine hydrochloride.

Technology Process of 4-Bromopiperidine hydrobromide

There total 1 articles about 4-Bromopiperidine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-bromopiperidine hydrobromide (54288-70-9)

Guidance literature:

With hydrogen bromide; at 150 ℃; im Rohr;

Reference yield: 98.0%

4-[(dipropylamino)sulfonyl]benzoic acid (57-66-9) + 4-bromopiperidine hydrobromide (54288-70-9) → 4-(4-bromopiperidine-1-carbonyl)-N, N-di-propylbenzenesulfonamide

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.chempr.2020.04.006

Reference yield: 98.0%

4-bromopiperidine hydrobromide (54288-70-9) + benzoyl chloride (98-88-4) → 1-Benzoyl-4-bromopiperidine (122374-26-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h; Cooling with ice;

DOI:10.1016/j.ejmech.2015.06.035

Downstream raw materials:

tert-butyl 4-bromo-1-piperidinecarboxylate

4-bromo-1-tosylpiperidine

benzyl 4-bromo-1-piperidinecarboxylate

C₃₂H₄₆N₂O₃