Tetralysine

Base Information

• Chemical Name: Tetralysine
• CAS No.: 997-20-6
• Molecular Formula: C24H50 N8 O5
• Molecular Weight: 530.712
• DSSTox Substance ID: DTXSID80912536
• Nikkaji Number: J1.196.822H
• Wikidata: Q82882832
• Mol file: 997-20-6.mol

Synonyms:tetralysine;tetralysine, (L-lysyl-D-lysyl-L-lysyl-L-lysine)-isomer

Chemical Property of Tetralysine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 901.2°C at 760 mmHg
• Flash Point: 498.8°C
• PSA: 254.70000
• Density: 1.161g/cm³
• LogP: 3.04290
• Storage Temp.: −20°C
• XLogP3: -4.7
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 23
• Exact Mass: 530.39041673
• Heavy Atom Count: 37
• Complexity: 667

Purity/Quality:

99%+, ^*data from raw suppliers

Lys-Lys-Lys-Lys ≥95% (TLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CCN)CC(C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N
• Isomeric SMILES: C(CCN)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)N

Technology Process of Tetralysine

There total 14 articles about Tetralysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-lysine ethyl ester dihydrochloride (3844-53-9,5721-12-0) → lysine tetrapeptide (997-20-6) + L-lysine (56-87-1,3506-25-0) + dilysine (13184-13-9) + Lys-Lys-Lys (13184-14-0)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) trypsin, sodium carbonate buffer pH 10.0, 25 deg C, 3 h, 2.) 60 deg C, 15 min;

Reference yield:

L-lysine ethyl ester dihydrochloride (3844-53-9,5721-12-0) → lysine tetrapeptide (997-20-6) + poly(L-lysine), 5-mer (19431-21-1) + L-lysine (56-87-1,3506-25-0) + dilysine (13184-13-9) + Lys-Lys-Lys (13184-14-0) + hexalysine (554-38-1)

Guidance literature:

multistep reaction; 1.) trypsin, Na₂CO₃ buffer pH 10.0, 25 deg C, 2.) NaOH, 60 deg C, 15 min; trypsin-catalyzed oligomerization of L-lysine esters, pH-dependence, reaction rate, kinetics, effect of NaCl; other L-lysin alkyl esters, enzyme or amino acids;

Reference yield:

L-lysine ethyl ester dihydrochloride (3844-53-9,5721-12-0) → lysine tetrapeptide (997-20-6) + poly(L-lysine), 5-mer (19431-21-1) + Lys-Lys-Lys (13184-14-0) + lysine peptide K8 (21743-34-0)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given; 1.) trypsin, sodium carbonate buffer pH 10.0, 25 deg C, 1 h, 2.) 60 deg C, 15 min;

upstream raw materials:

L-lysine ethyl ester dihydrochloride

L-lysine n-butyl ester di-p-toluene sulfonate

L-lysine n-hexyl ester di-p-toluene sulfonate

L-glutamic acid

Refernces

• 1、 Aso, Keiichi,Kodaka, Hiroaki. "Trypsin-catalyzed Oligomerization of L-Lysine Esters". . p. 755 - 758. Retrieved 2007/10/02.