N-Acetyl-L-aspartic acid anhydride

Base Information

• Chemical Name: N-Acetyl-L-aspartic acid anhydride
• CAS No.: 41148-79-2
• Molecular Formula: C6H7NO4
• Molecular Weight: 157.126
• Hs Code.: 2924199090
• Mol file: 41148-79-2.mol

Synonyms:n-(2,5-dioxooxolan-3-yl)acetamide;N-Acetyl L-aspartic anhydride;N-[(S)-Tetrahydro-2,5-dioxofuran-3-yl]acetamide;Nsc128612;N-(2,5-Dioxotetrahydrofuran-3-yl)acetaMide

Chemical Property of N-Acetyl-L-aspartic acid anhydride

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 141 °C
• Refractive Index: 1.492
• Boiling Point: 479.3 °C at 760 mmHg
• PKA: 13.71±0.20(Predicted)
• Flash Point: 243.7 °C
• PSA: 72.47000
• Density: 1.36 g/cm³
• LogP: -0.64450
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-N-(2,5-Dioxotetrahydrofuran-3-yl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Acetyl-L-aspartic acid anhydride

There total 4 articles about N-Acetyl-L-aspartic acid anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-Acetyl-L-aspartic acid (997-55-7) → (S)-N-acetyl-L-aspartic anhydride (41148-79-2)

Guidance literature:

With acetic anhydride; at 20 - 80 ℃; for 5h;

Reference yield:

→ (S)-N-acetyl-L-aspartic anhydride (41148-79-2)

Guidance literature:

With acetic anhydride;

DOI:10.1039/jr9530000453

Reference yield:

N-acetyl-DL-aspartic acid (2545-40-6) + water (7732-18-5) + acetic anhydride (108-24-7) → (S)-N-acetyl-L-aspartic anhydride (41148-79-2)

Guidance literature:

at 95 ℃; N-acetyl-aspartic acid;

DOI:10.1039/jr9530000453

upstream raw materials:

N-acetyl-DL-aspartic acid

water

acetic anhydride

N-Acetyl-L-aspartic acid

Downstream raw materials:

(S)-5-carboxymethyl-3-methyl-3-phenyltetramic acid

(S)-1-acetyl-5-carboxymethyl-3-ethoxycarbonyl-tetramic acid

(S)-1-acetyl-5-carboxymethyl-3-methoxycarbonyl-tetramic acid

(S)-5-carboxymethyl-3,3-dimethyltetramic acid

Refernces

• 1、 Witiak,Muhi-Eldeen,Mahishi,Sethi,Gerald. "L(S)- and D(R)-3-amino-1-phenylpyrrolidines. Stereoselective antagonists for histamine and acetylcholine receptors in vitro.". . p. 24 - 30. Retrieved 2007/10/05.