THIARABINE

Base Information

• Chemical Name: THIARABINE
• CAS No.: 26599-17-7
• Molecular Formula: C9H13 N3 O4 S
• Molecular Weight: 259.286
• Mol file: 26599-17-7.mol

Synonyms:Cytosine,1-(4-thio-b-D-arabinofuranosyl)- (8CI);4'-Thio-1-b-D-arabinofuranosylcytosine;4'-Thioaracytidine; OSI 7836; Thio-Cytarabine

Chemical Property of THIARABINE

Chemical Property:

• Boiling Point: 535°Cat760mmHg
• PKA: 13.41±0.70(Predicted)
• Flash Point: 277.3°C
• PSA: 147.89000
• Density: 1.9g/cm³
• LogP: -1.50400

Purity/Quality:

99%, ^*data from raw suppliers

THIARABINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of THIARABINE

There total 5 articles about THIARABINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(5-O-dimethyoxytrityl-4-thio-β-D-arabinofuranosyl)cytosine (255396-09-9) → TaraC (26599-17-7)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 20 ℃; for 0.166667h;

DOI:10.1080/15257770008033012

Reference yield: 85.0%

→ TaraC (26599-17-7)

Guidance literature:

Reference yield:

1-(2,3,5-tri-O-benzyl-4-thio-α,β-D-arabinofuranosyl)cytosine → TaraC (26599-17-7) + 1-(4-thio-α-D-arabinofuranosyl)cytosine

Guidance literature:

With boron trichloride; In dichloromethane; at -20 ℃; Title compound not separated from byproducts;

DOI:10.1080/15257770008033012

upstream raw materials:

1-(5-O-dimethyoxytrityl-4-thio-β-D-arabinofuranosyl)cytosine

1-(4-thio-α,β-D-arabinofuranosyl)cytosine

Downstream raw materials:

1-(5-O-dimethyoxytrityl-4-thio-β-D-arabinofuranosyl)cytosine

Refernces

• 1、 Ototani,Whistler. "Preparation and antitumor activity of 4' thio analogs of 2,2' anhydro 1 β D arabinofuranosylcytosine". . p. 535 - 537. Retrieved 1974.
• 2、 -. "Preparation of thioarabinofuranosyl compounds and use thereof". . . Retrieved 2008/06/13.