2,4-DIFLUOROPHENYL ISOTHIOCYANATE

Base Information

• Chemical Name: 2,4-DIFLUOROPHENYL ISOTHIOCYANATE
• CAS No.: 141106-52-7
• Molecular Formula: C7H3F2NS
• Molecular Weight: 171.17
• Hs Code.: 29309090
• Mol file: 141106-52-7.mol

Synonyms:2,4-Difluorophenylisothiocyanate;2,4-Difluoro-1-isothiocyanato-benzene;2,4-Difluoro-1-isothiocyanatobenzene;2,4-difluorobenzenisothiocyanate;

Chemical Property of 2,4-DIFLUOROPHENYL ISOTHIOCYANATE

Chemical Property:

• Refractive Index: n20/D 1.598(lit.)
• Boiling Point: 224.805 °C at 760 mmHg
• Flash Point: 89.759 °C
• PSA: 44.45000
• Density: 1.26 g/cm³
• LogP: 2.69910
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluorophenyl Isothiocyanate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 23-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,4-Difluorophenyl isothiocyanate may be used in the synthesis of the following 2-(4-(4-X-phenylsulfonyl)benzoyl)-N-(2,4-difluorophenyl)hydrazinecarbothioamides:N-(2,4-difluorophenyl)-2-(4-(phenylsulfonyl)benzoyl)hydrazinecarbothioamide2-(4-(4-chlorophenylsulfonyl)benzoyl)-N-(2,4-difluorophenyl)hydrazinecarbothioamide2-(4-(4-bromophenylsulfonyl)benzoyl)-N-(2,4-difluorophenyl)hydrazinecarbothioamide

Technology Process of 2,4-DIFLUOROPHENYL ISOTHIOCYANATE

There total 8 articles about 2,4-DIFLUOROPHENYL ISOTHIOCYANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2,4-difluoro-phenyl)-dithiocarbamic acid; compound with triethyl-amine → 2,4-difluorophenyl isothiocyanate (141106-52-7)

Guidance literature:

With iodine; triethylamine; In acetonitrile; at 5 ℃; Cooling with ice;

DOI:10.1002/ejoc.200801270

Reference yield:

C7H4F2NS2(1-) → 2,4-difluorophenyl isothiocyanate (141106-52-7)

Guidance literature:

With bis(trichloromethyl) carbonate; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.cclet.2017.10.015

Reference yield:

thiophosgene (463-71-8) + 2,4-difluorophenylamine (367-25-9,76563-56-9) → 2,4-difluorophenyl isothiocyanate (141106-52-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

upstream raw materials:

carbon disulfide

2,4-difluorophenylamine

N,N-Dimethylthiocarbamoyl chloride

thiophosgene

Downstream raw materials:

(2,4-Difluoro-phenyl)-thiazolidin-(2E)-ylidene-amine

N-(2,4-Difluorophenyl)-N'-(3,4-difluorophenyl)thiourea

1-(2,4-difluoro-phenyl)-3-(2,2-dimethyl-propyl)-2-thioxo-imidazolidine-4,5-dione

1-(2,4-difluoro-phenyl)-2-thioxo-3-(1,2,2-trimethyl-propyl)-imidazolidine-4,5-dione

Refernces

• 1、 Klug, Trevan,Cronin, Adam,O'Brien, Eli,Schioldager, Ryan,Johnson, Hunter,Gleason, Cameron,Schmid, Connor,Soderberg, Nathan,Manjunath, Aashrita,Liyanage, Duminda,Lazaro, Horacio,Kimball, Joshua J.,Eagon, Scott. "Microwave mediated synthesis of 2-aminooxazoles". . . Retrieved 2021/12/14.
• 2、 Sun, Haiyang,Li, Hui,Wang, Jiayi,Song, Gonghua. "Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin". . p. 977 - 980. Retrieved 2017/11/16.