2-fluoro-3,4-dimethoxybenzoic acid

Base Information

• Chemical Name: 2-fluoro-3,4-dimethoxybenzoic acid
• CAS No.: 2967-96-6
• Molecular Formula: C9H9 F O4
• Molecular Weight: 200.166
• Mol file: 2967-96-6.mol

Synonyms:Veratricacid, 2-fluoro- (6CI,8CI); NSC 400849

Chemical Property of 2-fluoro-3,4-dimethoxybenzoic acid

Chemical Property:

• Vapor Pressure: 0.000926mmHg at 25°C
• Boiling Point: 290.9°Cat760mmHg
• Flash Point: 129.7°C
• Density: 1.298g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-fluoro-3,4-dimethoxybenzoic acid

There total 5 articles about 2-fluoro-3,4-dimethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-fluoro-3,4-dimethoxybenzaldehyde (37686-68-3) → 2-fluoro-3,4-dimethoxybenzoic acid (2967-96-6)

Guidance literature:

With sodium chlorite; dihydrogen peroxide; In acetonitrile; at 0 - 20 ℃; for 5h;

DOI:10.1016/j.bmc.2019.02.040

Reference yield:

2-fluoro-3,4-dimethoxy-benzoic acid methyl ester (778-68-7) → 2-fluoro-3,4-dimethoxybenzoic acid (2967-96-6)

Guidance literature:

With sodium hydroxide;

Reference yield:

1-fluoro-2,3-dimethoxybenzene (394-64-9) → 2-fluoro-3,4-dimethoxybenzoic acid (2967-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 81.8 percent / AlCl₃ / 1,2-dichloro-ethane / 2.5 h / -20 - 20 °C

2: 62 percent / Br₂ / CHCl₃ / 2 h / Ambient temperature

3: 1.) diethylamine, 2.) conc. HCl / 1.) i-Pr-OH, RT, 6 h, 2.) i-PrOH

With hydrogenchloride; aluminium trichloride; bromine; diethylamine; In chloroform; 1,2-dichloro-ethane;

upstream raw materials:

2-fluoro-3,4-dimethoxy-benzoic acid methyl ester

2-Bromo-1-(2-fluoro-3,4-dimethoxy-phenyl)-ethanone

1-fluoro-2,3-dimethoxybenzene

1-(2-fluoro-3,4-dimethoxyphenyl)ethanone

Refernces

• 1、 Stegmann, Hartmut B.,Deuschle, Gabriele,Schuler, Paul. "Synthesis and EPR Investigations of Fluorocatecholamines". . p. 547 - 556. Retrieved 2007/10/02.