ethoxyfluorescein ethyl ester

Base Information

• Chemical Name: ethoxyfluorescein ethyl ester
• CAS No.: 87569-96-8
• Molecular Formula: C24H20 O5
• Molecular Weight: 388.42
• Hs Code.: 2932999099
• Mol file: 87569-96-8.mol

Synonyms:3H-Isoxanthen-3-one,9-(o-carboxyphenyl)-6-ethoxy-, ethyl ester (5CI); Ethoxyfluorescein ethyl ester

Chemical Property of ethoxyfluorescein ethyl ester

Chemical Property:

• Vapor Pressure: 1.31E-14mmHg at 25°C
• Boiling Point: 605.4°C at 760 mmHg
• Flash Point: 339.2°C
• PSA: 65.74000
• Density: 1.3g/cm³
• LogP: 5.14020

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethoxyfluorescein ethyl ester

There total 9 articles about ethoxyfluorescein ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl iodide (75-03-6) + fluorescein free acid (518-45-6) → 2-(6'-ethoxy-3'-oxo-3'H-xanthene-9'-yl)benzoic acid ethyl ester (87569-96-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

DOI:10.1007/s10895-021-02789-y

Reference yield:

ethyl bromide (74-96-4) → 2-(6'-ethoxy-3'-oxo-3'H-xanthene-9'-yl)benzoic acid ethyl ester (87569-96-8)

Guidance literature:

With ethanol; sodium ethanolate; at 100 ℃; lactoider Fluorescein-diaethylaether;

Reference yield:

recorcinol (108-46-3) → 2-(6'-ethoxy-3'-oxo-3'H-xanthene-9'-yl)benzoic acid ethyl ester (87569-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc chloride / 180 °C

With zinc(II) chloride;

upstream raw materials:

Diazoethan

fluorescein

ethyl bromide

ethyl iodide

Downstream raw materials:

2-(3'-hydroxy-6'-ethoxy-9'H-xanthen-9'-yl)phenylethyl alcohol

C₂₄H₂₂O₅

ethyl fluorescein

Refernces

• 1、 AlRabiah, Haitham,Kadi, Adnan A.,Lu, Yang,Mahajumi, Abu Syed,Mostafa, Gamal A. E.,Rahman, A. F. M. Motiur. "Synthesis and Photophysical Properties of Fluorescein Esters as Potential Organic Semiconductor Materials". . p. 1489 - 1502. Retrieved 2021/07/26.