piperidin-1-yl(pyridin-4-yl)methanone

Base Information

• Chemical Name: piperidin-1-yl(pyridin-4-yl)methanone
• CAS No.: 4968-87-0
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.24
• Mol file: 4968-87-0.mol

Synonyms:isonicotinic acid piperidide;Piperidin-1-yl-pyridin-4-yl-methanone;Isonicotin-piperidin;Isonicotinsaeure-piperidid;1-(4-pyridinecarbonyl)piperidine;

Chemical Property of piperidin-1-yl(pyridin-4-yl)methanone

Chemical Property:

• Boiling Point: 345.3±15.0 °C(Predicted)
• PKA: 4.56±0.10(Predicted)
• PSA: 33.20000
• Density: 1.134±0.06 g/cm3(Predicted)
• LogP: 1.64560

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of piperidin-1-yl(pyridin-4-yl)methanone

There total 10 articles about piperidin-1-yl(pyridin-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

piperidine (110-89-4) + pyridine-4-carbaldehyde (872-85-5) → piperidin-1-yl(pyridin-4-yl)methanone (4968-87-0)

Guidance literature:

With sodium 5-methyl-2-pyridonate; [Cu₄(μ₃-I)4(Pip)₄]; In toluene; at 110 ℃; for 20h; Molecular sieve;

DOI:10.1021/jo301553v

Reference yield: 82.0%

piperidine (110-89-4) + isonicotinic acid ethylester (1570-45-2) → piperidin-1-yl(pyridin-4-yl)methanone (4968-87-0)

Guidance literature:

With potassium tert-butylate; water; oxygen; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1055/s-0031-1289622

Reference yield: 80.0%

piperidine (110-89-4) + 4-iodopyridine (15854-87-2) + carbon monoxide (201230-82-2) → piperidin-1-yl(pyridin-4-yl)methanone (4968-87-0) + 1-piperidin-1-yl-2-pyridin-4-yl-ethane-1,2-dione

Guidance literature:

palladium diacetate; tricyclohexylphosphine; In dichloromethane; at 50 ℃; for 23h; under 45600 Torr;

DOI:10.1002/1615-4169(20010330)343:3<289::AID-ADSC289>3.0.CO;2-1

upstream raw materials:

piperidine

pyridine-4-carboxylic acid

4-iodopyridine

carbon monoxide

Downstream raw materials:

N-Methyl-N-benzyl-isonicotinamid

1-(piperidin-4-ylcarbonyl)piperidine hydrochloride

4-(Piperidine-1-carbonyl)-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(piperidine-1-carbonyl)-piperidine-1-carboximidothioic acid methyl ester

Refernces

• 1、 Alexanian, Erik J.,Veatch, Alexander M.. "Cobalt-catalyzed aminocarbonylation of (hetero)aryl halides promoted by visible light". . p. 7210 - 7213. Retrieved 2020/07/23.
• 2、 Pandey, Ganesh,Koley, Suvajit,Talukdar, Ranadeep,Sahani, Pramod Kumar. "Cross-Dehydrogenating Coupling of Aldehydes with Amines/R-OTBS Ethers by Visible-Light Photoredox Catalysis: Synthesis of Amides, Esters, and Ureas". supporting information. p. 5861 - 5865. Retrieved 2018/09/21.