1-(2-Naphthyl)ethanol

Base Information

• Chemical Name: 1-(2-Naphthyl)ethanol
• CAS No.: 7228-47-9
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Hs Code.: 2906290090
• European Community (EC) Number: 230-630-3
• NSC Number: 92277
• Nikkaji Number: J212.253G
• Wikidata: Q72493738
• Mol file: 7228-47-9.mol

Synonyms:1-(2-naphthyl)ethanol

Chemical Property of 1-(2-Naphthyl)ethanol

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 2.32E-13mmHg at 25°C
• Melting Point: 73-78 °C(lit.)
• Refractive Index: 1.589
• Boiling Point: 316 °C at 760 mmHg
• PKA: 14.36±0.20(Predicted)
• Flash Point: 145.3 °C
• PSA: 20.23000
• Density: 1.119g/cm³
• LogP: 2.37460
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Toluene
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 172.088815002
• Heavy Atom Count: 13
• Complexity: 167

Purity/Quality:

98.0%Min ^*data from raw suppliers

1-(Naphthalen-2-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C1=CC2=CC=CC=C2C=C1)O
• Uses: 1-(Naphthalen-2-yl)ethanol is a reagent used in the chemical-enzymic preparation and resolution of β-naphthyl alcohols. A cinacalcet impurity.

Technology Process of 1-(2-Naphthyl)ethanol

There total 68 articles about 1-(2-Naphthyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(1-napthalenylethoxy)-tetrahydropyran (88773-87-9) → 2-(2-naphthyl)ethanol (7228-47-9)

Guidance literature:

Nafion-H; In methanol; for 2h;

DOI:10.1055/s-1983-30553

Reference yield: 97.0%

2-acetylnaphthone (33867-96-8) → 2-(2-naphthyl)ethanol (7228-47-9)

Guidance literature:

With C₅₆H₅₅ClN₃P₂Ru⁽¹⁺⁾*F₆P^(1-); potassium 2-methylbutan-2-olate; In isopropyl alcohol; at 20 - 80 ℃; for 1.5h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201304770

Reference yield: 95.0%

2-ethylnaphthalene (939-27-5) → 2-(2-naphthyl)ethanol (7228-47-9)

Guidance literature:

With C₂₀H₂₄B₁₀Br₂Cl₂FeN₆; dihydrogen peroxide; In methanol; at 20 ℃; for 8h;

upstream raw materials:

methyl 2-naphthyl ketone

2-(1-chloroethyl)naphthalene

2-naphthylethylene

1-(2-naphthyl)ethyl acetate

Downstream raw materials:

benzhydryl ether

2,2'-(1,1'-oxybis(ethane-1,1-diyl))dinaphthalene

2-(1-Benzhydryloxy-ethyl)-naphthalene

(S)-1-(2-Naphthyl)ethanol

Refernces

• 1、 Du, Xinyu,Qi, Xinghao,Li, Kai,Li, Xiaoyan,Sun, Hongjian,Fuhr, Olaf,Fenske, Dieter. "Synthesis and catalytic activity of N-heterocyclic silylene (NHSi) iron (II) hydride for hydrosilylation of aldehydes and ketones". . . Retrieved 2021/05/29.
• 2、 Dai, Zengjin,Pan, Ying-Min,Wang, Shou-Guo,Yin, Qin,Zhang, Xumu. "Direct reductive amination of ketones with ammonium salt catalysed by Cp*Ir(iii) complexes bearing an amidato ligand". supporting information. p. 8934 - 8939. Retrieved 2021/11/04.