3-Aminopyrazine-2-carboxamide

Base Information

• Chemical Name: 3-Aminopyrazine-2-carboxamide
• CAS No.: 32587-10-3
• Molecular Formula: C5H6N4O
• Molecular Weight: 138.129
• Hs Code.: 2934999090
• NSC Number: 131841,241332
• UNII: 3K43224J9U
• DSSTox Substance ID: DTXSID90186281
• Wikidata: Q72441397
• Mol file: 32587-10-3.mol

Synonyms:3-aminopyrazine-2-carboxamide;32587-10-3;Aminopyrazine carboxamide;3-aminopyrazinecarboxamide;Pyrazinecarboxamide, 3-amino- (7CI,9CI);3-amino-2-pyrazinecarboxamide;NSC131841;NSC241332;3K43224J9U;NSC-131841;NSC-241332;NSC 241332;aminopyrazinamide;NSC 131841;3-AMINO-PYRAZINE-2-CARBOXYLIC ACID AMIDE;3-amino-pyrazine-2-carboxamide;SCHEMBL1097431;3-AMINOPYRAZINCARBOXAMIDE;PYRAZINAMIDE, 3-AMINO-;UNII-3K43224J9U;DTXSID90186281;SFSMATGDLFHTHE-UHFFFAOYSA-N;2-AMINO-3-CARBAMOYLPYRAZINE;MFCD03407446;2-AMINOPYRAZINE-3-CARBOXAMIDE;PYRAZINECARBOXAMIDE, 3-AMINO-;AKOS005206853;AB14047;2-PYRAZINECARBOXAMIDE, 3-AMINO-;AC-27253;TS-00036;CS-0149924;FT-0660516;A23242;EN300-252453;Z1198161815

Chemical Property of 3-Aminopyrazine-2-carboxamide

Chemical Property:

• Vapor Pressure: 7.56E-06mmHg at 25°C
• Melting Point: 239.3 °C
• Refractive Index: 1.656
• Boiling Point: 375.8 °C at 760 mmHg
• PKA: 13.68±0.50(Predicted)
• Flash Point: 181.1 °C
• PSA: 94.89000
• Density: 1.426 g/cm³
• LogP: 0.43920
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 138.05416083
• Heavy Atom Count: 10
• Complexity: 138

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Aminopyrazine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=N1)C(=O)N)N

Technology Process of 3-Aminopyrazine-2-carboxamide

There total 20 articles about 3-Aminopyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Methyl 3-amino-2-pyrazinecarboxylate (16298-03-6) → 3-aminopyrazine-2-carboxamide (32587-10-3)

Guidance literature:

With ammonia; In water; at 20 ℃; for 12h;

DOI:10.1002/jhet.883

Reference yield: 80.0%

2-Cyano-3-<(dimethylaminomethylene)amino>pyrazine (34859-38-6) → 2-amino-3-pyrazinonitrile (25911-65-3) + 3-aminopyrazine-2-carboxamide (32587-10-3) + 2-aminopyrazine-3-carboxamide oxime (76952-35-7) + 4-aminopteridine 3-oxide (76952-40-4)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; for 0.666667h; Heating;

Reference yield: 53.0%

2-Aminopyrazine (5049-61-6) + formamide (77287-34-4,77287-35-5,60100-09-6) → 3-aminopyrazine-2-carboxamide (32587-10-3)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; iron(II) sulfate; at 0 - 15 ℃; for 15h;

upstream raw materials:

Methyl 3-amino-2-pyrazinecarboxylate

1,2-dihydro-pyrazolo[3,4-b]pyrazin-3-one

formamide

Glyoxal

Downstream raw materials:

pteridin-4-one

3-[(N-acetyl-sulfanilyl)-amino]-pyrazine-2-carboxylic acid amide

2-amino-3-pyrazinonitrile

3-aminopyrazinoic acid

Refernces

• 1、 -. "Pteridine derivative and pharmaceutical composition containing same". Paragraph 0050; 0051; 0052. . Retrieved 2017/07/19.
• 2、 Duan, Chonggang,Jia, Jiong,Zhu, Rongxiu,Wang, Jianwu. "Synthesis of N-substituted-6-alkoxypteridin-4-amine". . p. 865 - 872. Retrieved 2012/10/29.