5-Chloro-6-hydroxy-3-pyridinecarboxylic acid

Base Information

• Chemical Name: 5-Chloro-6-hydroxy-3-pyridinecarboxylic acid
• CAS No.: 54127-63-8
• Molecular Formula: C6H4ClNO3
• Molecular Weight: 173.556
• Hs Code.: 2933399090
• Mol file: 54127-63-8.mol

Synonyms:5-chloro-6-hydroxynicotinic acid;3-Chloro-2-hydroxypyridine-5-carboxylicacid;

Chemical Property of 5-Chloro-6-hydroxy-3-pyridinecarboxylic acid

Chemical Property:

• Appearance/Colour: white to beige fine crystalline powder
• Vapor Pressure: 2.42E-05mmHg at 25°C
• Melting Point: ≥300 °C(lit.)
• Refractive Index: 1.5810 (estimate)
• Boiling Point: 334.6 °C at 760 mmHg
• PKA: 3.38±0.50(Predicted)
• Flash Point: 156.1 °C
• PSA: 70.42000
• Density: 1.62 g/cm₃
• LogP: 1.13880
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloro-6-hydroxynicotinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 5-Chloro-6-hydroxy-3-pyridinecarboxylic acid

There total 4 articles about 5-Chloro-6-hydroxy-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nicotinic acid (59-67-6) → 5-chloro-6-hydroxy-3-pyridinecarboxylic acid (54127-63-8)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; at 250 - 270 ℃; im Rohr; destillieren des Reaktionsprodukts mit Wasserdampf und Kochen des ueberdestillierten Oels mit Schwefelsaeure;

Reference yield:

5,6-dichloronicotinic acid (41667-95-2) → 5-chloro-6-hydroxy-3-pyridinecarboxylic acid (54127-63-8)

Guidance literature:

With potassium hydroxide;

Reference yield:

5-chloro-6-hydroxy-nicotinic acid methyl ester (316166-47-9) → 5-chloro-6-hydroxy-3-pyridinecarboxylic acid (54127-63-8)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

nicotinic acid

5-chloro-6-hydroxy-nicotinic acid methyl ester

5,6-dichloronicotinic acid

Downstream raw materials:

5-chloro-6-isopropoxynicotinic acid

5-chloro-N-(4-fluorophenyl)-6-hydroxynicotinamide

5-chloro-6-hydroxy-nicotinic acid methyl ester

2,3-dichloro-5-iodopyridine