5-FLUORO-1,3-DIMETHYLURACIL

Base Information

• Chemical Name: 5-FLUORO-1,3-DIMETHYLURACIL
• CAS No.: 3013-92-1
• Molecular Formula: C6H7 F N2 O2
• Molecular Weight: 158.132
• Hs Code.: 2933599090
• Mol file: 3013-92-1.mol

Synonyms:Uracil,5-fluoro-1,3-dimethyl- (7CI,8CI); 1,3-Dimethyl-5-fluorouracil;5-Fluoro-1,3-dimethyluracil; NSC 379683

Chemical Property of 5-FLUORO-1,3-DIMETHYLURACIL

Chemical Property:

• Vapor Pressure: 0.81mmHg at 25°C
• Melting Point: 132-134 °C(lit.)
• Boiling Point: 182.5°Cat760mmHg
• PKA: -4.07±0.40(Predicted)
• Flash Point: 64.1°C
• PSA: 44.00000
• Density: 1.37g/cm³
• LogP: -0.77690

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-1,3-dimethyluracil 99% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 5-Fluoro-1,3-dimethyluracil may be used as starting material in the following processes:Regioselective synthesis of tetrahydronaphthocyclobuta[1,2-d]pyrimidinediones.To synthesize 5-bis(ethoxycarbonyl)methyl-1,3-dimethyluracil.To synthesize new highly conjugated propenylidene derivatives via aromatic Paterno-Buchi type cycloaddition with 1-methoxynaphthalene.

Technology Process of 5-FLUORO-1,3-DIMETHYLURACIL

There total 2 articles about 5-FLUORO-1,3-DIMETHYLURACIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

4a-fluoro-4a,5,10,10a-tetrahydro-1,3-dimethyl-5,10-ethenobenzo[f]quinazoline-2,4-dione → 8e-fluoro-2,4-dimethyl-4a,4b,8b,8c,8d,8e-hexahydro-4H-2,4-diaza-dibenzo[a,f]cyclopropa[cd]pentalene-1,3-dione + naphthalene (91-20-3,71998-51-1,72931-45-4) + 1,3-dimethyl-5-fluorouracil (3013-92-1)

Guidance literature:

In cyclohexane; for 0.25h; UV-irradiation;

DOI:10.3987/COM-05-10520

Reference yield: 12.0%

5-fluorouracil (51-21-8) + methyl iodide (74-88-4) → 1-Methyl-5-fluor-uracil (155-16-8) + 5-fluoro-3-methyl-1H-pyrimidine-2,4-dione (4840-69-1) + 1,3-dimethyl-5-fluorouracil (3013-92-1)

Guidance literature:

With potassium carbonate; In acetone; at 60 - 70 ℃; for 24h;

DOI:10.1248/cpb.39.1922

Reference yield: 74.0%

benzophenone (119-61-9) + 1,3-dimethyl-5-fluorouracil (3013-92-1) → C32H29FN2O3 (1346676-20-7)

Guidance literature:

benzophenone; 1,3-dimethyl-5-fluorouracil; With titanium tetrachloride; zinc; In tetrahydrofuran; at 0 - 25 ℃; for 6h;

With water; sodium hydrogencarbonate; In tetrahydrofuran; at 0 - 25 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2011.09.154

upstream raw materials:

5-fluorouracil

methyl iodide

Downstream raw materials:

5-fluoroisocytosine

3-Chloro-benzoic acid 1,3-dimethyl-2,5-dioxo-imidazolidin-4-yl ester

5-fluoro-2,6-dihydroxynicotinamide

5-Fluoro-2-hydroxy-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid amide

Refernces

• 1、 Ishikawa,Itoh,Takayanagi,Oshima,Kawahara,Mizuno,Ogura. "The photocycloaddition reactions of uridine and related compounds with 2,3-dimethyl-2-butene". . p. 1922 - 1930. Retrieved 2007/10/02.