1-methylorotic acid

Base Information

• Chemical Name: 1-methylorotic acid
• CAS No.: 705-36-2
• Molecular Formula: C6H6 N2 O4
• Molecular Weight: 170.125
• Mol file: 705-36-2.mol

Synonyms:Oroticacid, 1-methyl- (6CI,7CI,8CI); 1-Methylorotic acid

Chemical Property of 1-methylorotic acid

Chemical Property:

• Vapor Pressure: 6.9E-07mmHg at 25°C
• Refractive Index: 1.5100 (estimate)
• Boiling Point: 367.3°C at 760 mmHg
• Flash Point: 175.9°C
• PSA: 92.42000
• Density: 1.545g/cm³
• LogP: -0.81590
• Water Solubility.: 20.42g/L(20 oC)

Purity/Quality:

99% ^*data from raw suppliers

6-Hydroxy-1-methyl-2-oxo-1,2-dihydro-4-pyrimidinecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methylorotic acid

There total 4 articles about 1-methylorotic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

orotic acid (65-86-1,58915-47-2,6784-70-9) + dimethyl sulfate (77-78-1) → 1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid (705-36-2)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/0006-3002(57)90331-1

Reference yield:

(1-methyl-2,5-dioxo-imidazolidin-4-ylidene)-acetic acid ethyl ester (712-92-5) → 1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid (705-36-2)

Guidance literature:

With sodium hydroxide;

Reference yield:

N-Methylurea (598-50-5) + diethyl oxaloacetate (108-56-5) → 1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid (705-36-2)

Guidance literature:

With hydrogenchloride; potassium hydroxide; Multistep reaction; 1.) acetic acid, 100 deg C, 0.5 h; 2.) ethanol, water, reflux, 2 h;

DOI:10.1039/DT9950004005

upstream raw materials:

(1-methyl-2,5-dioxo-imidazolidin-4-ylidene)-acetic acid ethyl ester

orotic acid

dimethyl sulfate

N-Methylurea

Downstream raw materials:

N-(2,4-dichlorobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide

3-methyluracil

Refernces

• 1、 Dodin, Guy,Dubois, Jacques-Emile. "Tautomerism of Orotic Acid Dianion. Effect of Calcium and Magnesium Cations on the Tautomeric Constant and on Tautomerization Dynamics". . p. 3049 - 3056. Retrieved 2007/10/02.