ethyl P-phenylphosphonamidate

Base Information

• Chemical Name: ethyl P-phenylphosphonamidate
• CAS No.: 5326-06-7
• Molecular Formula: C8H12NO2P
• Molecular Weight: 185.163
• Mol file: 5326-06-7.mol

Synonyms:

Chemical Property of ethyl P-phenylphosphonamidate

Chemical Property:

• Vapor Pressure: 0.00298mmHg at 25°C
• Boiling Point: 284.4°Cat760mmHg
• Flash Point: 125.8°C
• Density: 1.16g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl P-phenylphosphonamidate

There total 5 articles about ethyl P-phenylphosphonamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

ethanol (64-17-5) + phenylphosphonic diamide (4707-88-4) → Phenylphosphonic acid monoethyl ester amide (5326-06-7)

Guidance literature:

at 100 ℃; Reflux; Sealed tube;

DOI:10.1002/chem.201805039

Reference yield:

ethyl Phenylphosphinate (172487-18-2,2511-09-3) + benzaldehyde benzylidenehydrazone (28867-76-7) → Phenylphosphonic acid monoethyl ester amide (5326-06-7) + benzaldehyde (100-52-7)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1) THF 2) 0.5 h, reflux;

Reference yield:

P,P-dichlorophenylphosphine oxide (824-72-6) → Phenylphosphonic acid monoethyl ester amide (5326-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃

With ammonia;

DOI:10.1021/jo01354a010

upstream raw materials:

P,P-dichlorophenylphosphine oxide

ethanol

phenylphosphonic diamide

ethyl Phenylphosphinate

Refernces

• 1、 Nocentini, Alessio,Gratteri, Paola,Supuran, Claudiu T.. "Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide-Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors". supporting information. p. 1188 - 1192. Retrieved 2019/01/04.