(6-Methylpyridin-2-yl)methanamine

Base Information

• Chemical Name: (6-Methylpyridin-2-yl)methanamine
• CAS No.: 6627-60-7
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 837-639-7
• NSC Number: 63906,60125
• DSSTox Substance ID: DTXSID50289287
• Nikkaji Number: J773.398D
• Wikidata: Q72496637
• Mol file: 6627-60-7.mol

Synonyms:(6-methylpyridin-2-yl)methanamine;6627-60-7;6-Methyl-2-pyridinemethanamine;2-aminomethyl-6-methylpyridine;2-(aminomethyl)-6-methylpyridine;2-pyridinemethanamine, 6-methyl-;2-Aminomethyl-6-methyl-pyridine;(6-Methyl-2-pyridinyl)methanamine;MFCD05864530;NSC63906;1-(6-methylpyridin-2-yl)methanamine;SCHEMBL904590;2-methyl-6-aminomethyl pyridine;(6-Methyl-2-pyridyl)methanamine;DTXSID50289287;NSC60125;Pyridine, 2-aminomethyl-6-methyl-;NSC 60125;NSC 63906;NSC-60125;NSC-63906;(6-Methyl-2-pyridinyl)methanamine #;[(6-methylpyridin-2-yl)methyl]amine;C-(6-Methylpyridin-2-yl)methylamine;AKOS000163973;AB22796;CS-W003929;AM804203;BS-13046;SY035072;1-(6-METHYL-2-PYRIDINYL)METHANAMINE;BB 0254864;FT-0657600;EN300-49537;C-(6-METHYL-PYRIDIN-2-YL)-METHYLAMINE;A835399;J-501684;Z291234028

Chemical Property of (6-Methylpyridin-2-yl)methanamine

Chemical Property:

• Vapor Pressure: 0.357mmHg at 25°C
• Refractive Index: 1.545
• Boiling Point: 198.6 °C at 760 mmHg
• PKA: 8.75±0.39(Predicted)
• Flash Point: 94.5 °C
• PSA: 38.91000
• Density: 1.027 g/cm³
• LogP: 1.54900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Methyl-2-pyridinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)CN
• Uses: (6-Methylpyridin-2-yl)methanamine is a pyridine derivative studied as one of the complexing agent.

Technology Process of (6-Methylpyridin-2-yl)methanamine

There total 2 articles about (6-Methylpyridin-2-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methanol (67-56-1) + 2-(azidomethyl)-6-methylpyridine (332179-68-7) → 2-aminomethyl-6-methylpyridine (6627-60-7) + N-methyl-(6-methyl-pyridin-2-yl)methylamine (6971-57-9)

Guidance literature:

With trans-RuCl(phenpyra-Me)(PPh₃)₂PF₆; sodium hydroxide; at 125 ℃; for 4h; Sealed tube; Inert atmosphere; Glovebox;

DOI:10.1039/c8gc00863a

Reference yield:

2-(bromomethyl)-6-methylpyridine (68470-59-7) → 2-aminomethyl-6-methylpyridine (6627-60-7) + N-methyl-(6-methyl-pyridin-2-yl)methylamine (6971-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / methanol / 16 h / 20 °C

2: sodium hydroxide; trans-RuCl(phenpyra-Me)(PPh₃)₂PF₆ / 4 h / 125 °C / Sealed tube; Inert atmosphere; Glovebox

With sodium azide; trans-RuCl(phenpyra-Me)(PPh₃)₂PF₆; sodium hydroxide; In methanol;

DOI:10.1039/c8gc00863a

Reference yield: 62.0%

2-aminomethyl-6-methylpyridine (6627-60-7) + 7-chloro-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine → 2,5-dimethyl-N-((6-methylpyridin-2-yl)methyl)-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 80 ℃; for 16h; Reflux;

DOI:10.1016/j.bmc.2015.10.021

upstream raw materials:

2-(bromomethyl)-6-methylpyridine

methanol

2-(azidomethyl)-6-methylpyridine

Downstream raw materials:

3-(2-{[(6-methyl-pyridin-2-ylmethyl)-amino]-methyl}-phenylsulfanyl)-propionitrile

3-(2-{[(6-methyl-pyridin-2-ylmethyl)-pyridin-2-ylmethyl-amino]-methyl}-phenylsulfanyl)-propionitrile

3-(2-{[bis-(6-methyl-pyridin-2-ylmethyl)-amino]-methyl}-phenylsulfanyl)-propionitrile

(+)-2-[(2R,5R)-2,5-diphenylpyrrolidin-1-yl]methyl-6-methylpyridine

Refernces