1-methylpiperidine-4-carbonyl chloride hydrochloride

Base Information

• Chemical Name: 1-methylpiperidine-4-carbonyl chloride hydrochloride
• CAS No.: 7462-84-2
• Molecular Formula: C7H12ClNO
• Molecular Weight: 198.092
• Mol file: 7462-84-2.mol

Synonyms:1-Methylpiperid-4-ylcarbonyl chloride hydrochloride;1-methyl-piperidine-4-carbonyl chloride.HCl;chloride of 1-methylpiperidine-4-carboxylic acid hydrochloride;N-methylisonipecotyl chloride hydrochloride;1-Methyl4-piperidinecarbonyl chloride hydrochloride;1-methyl-piperidine-4-carbonyl chloride hydrochloride;

Chemical Property of 1-methylpiperidine-4-carbonyl chloride hydrochloride

Chemical Property:

• Vapor Pressure: 0.472mmHg at 25°C
• Boiling Point: 193.1°Cat760mmHg
• Flash Point: 70.6°C
• PSA: 20.31000
• Density: 1.125g/cm³
• LogP: 1.83350

Purity/Quality:

95% purity ^*data from raw suppliers

1-methylpiperidine-4-carbonylchloridehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methylpiperidine-4-carbonyl chloride hydrochloride

There total 1 articles about 1-methylpiperidine-4-carbonyl chloride hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-methylpiperidine-4-carboxylic acid (68947-43-3) → 1-methylpiperidine-4-carbonyl chloride hydrochloride (7462-84-2)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h; Heating / reflux;

Reference yield: 91.0%

1-methylpiperidine-4-carbonyl chloride hydrochloride (7462-84-2) + C15H22N2OSi → C19H25N3O2

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃; for 20h;

Reference yield: 72.0%

1-methylpiperidine-4-carbonyl chloride hydrochloride (7462-84-2) + 3-((5-bromo-4-(5-(trifluoromethyl)pyridin-2-yl)oxazol-2-yl)methoxy)-2,6-difluorobenzamide → C24H20BrF5N4O4

Guidance literature:

1-methylpiperidine-4-carbonyl chloride hydrochloride; 3-((5-bromo-4-(5-(trifluoromethyl)pyridin-2-yl)oxazol-2-yl)methoxy)-2,6-difluorobenzamide; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.0833333h;

With water; In tetrahydrofuran; mineral oil; for 0.166667h;

upstream raw materials:

1-methylpiperidine-4-carboxylic acid

Downstream raw materials:

C₇H₁₃NO₂*C₃₁H₄₅N₃O₈*ClH

N-{5-[2,4-dihydroxy-6-(4-nitrophenoxy)phenyl]isoxazol-3-yl}-1-methylpiperidine-4-carboxamide

C₂₆H₂₉N₇O₂

Refernces

• 1、 -. "PYRIDINOYLPIPERIDINES AS 5-HT1F AGONISTS". Page/Page column 46. . Retrieved 2008/06/13.