6-chloro-4-ethoxyquinazoline

Base Information

• Chemical Name: 6-chloro-4-ethoxyquinazoline
• CAS No.: 7505-75-1
• Molecular Formula: C₁₀H₉ClN₂O
• Molecular Weight: 208.647
• Mol file: 7505-75-1.mol

Synonyms:NSC 400951

Chemical Property of 6-chloro-4-ethoxyquinazoline

Chemical Property:

• Vapor Pressure: 0.000245mmHg at 25°C
• Boiling Point: 334.7°Cat760mmHg
• Flash Point: 156.2°C
• Density: 1.284g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-4-ethoxyquinazoline

There total 4 articles about 6-chloro-4-ethoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloroquinazolin-4-one (16064-14-5) → 4-ethoxy-6-chloro-quinazoline (7505-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃; PCl₅

2: ethanol

With ethanol; phosphorus pentachloride; trichlorophosphate;

DOI:10.1021/ja01211a057

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 4-ethoxy-6-chloro-quinazoline (7505-75-1)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl ether; sulfuryl chloride

2: 180 °C

3: POCl₃; PCl₅

4: ethanol

With sulfuryl dichloride; diethyl ether; ethanol; phosphorus pentachloride; trichlorophosphate;

DOI:10.1021/ja01211a057

Reference yield:

5-chloroanthranilic acid (635-21-2) → 4-ethoxy-6-chloro-quinazoline (7505-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 180 °C

2: POCl₃; PCl₅

3: ethanol

With ethanol; phosphorus pentachloride; trichlorophosphate;

DOI:10.1021/ja01211a057

upstream raw materials:

4,6-dichloroquinazoline

sodium ethanolate

6-chloroquinazolin-4-one

anthranilic acid