ETHYL 2,5-DIMETHYL-3-FUROATE

Base Information

• Chemical Name: ETHYL 2,5-DIMETHYL-3-FUROATE
• CAS No.: 29113-63-1
• Molecular Formula: C9H12 O3
• Molecular Weight: 168.192
• Hs Code.: 2932190090
• Mol file: 29113-63-1.mol

Synonyms:3-Furoicacid, 2,5-dimethyl-, ethyl ester (6CI,7CI,8CI); 2,5-Dimethyl-3-furancarboxylicacid ethyl ester; Ethyl 2,5-dimethyl-3-furancarboxylate

Chemical Property of ETHYL 2,5-DIMETHYL-3-FUROATE

Chemical Property:

• Vapor Pressure: 0.213mmHg at 25°C
• Refractive Index: 1.4686 (estimate)
• Boiling Point: 208.5°Cat760mmHg
• Flash Point: 83°C
• PSA: 39.44000
• Density: 1.056g/cm³
• LogP: 2.07310

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2,5-dimethyl-3-furoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2,5-DIMETHYL-3-FUROATE

There total 37 articles about ETHYL 2,5-DIMETHYL-3-FUROATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl (2E)-3-(prop-2-yn-1-yloxy)but-2-enoate → ethyl 2,5-dimethyl-3-furoate (29113-63-1)

Guidance literature:

With 1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene(acetonitrile)gold(I) tetrafluoroborate; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol902716n

Reference yield: 88.0%

ethyl 2-acetyl-4-bromopent-4-enoate (90674-91-2) → ethyl 2,5-dimethyl-3-furoate (29113-63-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; silver carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 0.8h;

DOI:10.1039/c5ra14273c

Reference yield: 86.0%

ethyl 2-acetylpent-4-ynoate (36600-70-1,123325-96-2) → ethyl 2,5-dimethyl-3-furoate (29113-63-1)

Guidance literature:

With indium(III) triflate; In toluene; at 20 ℃; for 4h;

DOI:10.1055/s-0030-1259930

upstream raw materials:

Diazoethan

2,5-dimethylfuran-3-carboxylic acid

4-(carboethoxy)-5-methylfuran-2-acetic acid

ethyl 2-acetyl-4-oxopentanoate

Downstream raw materials:

2,5-dimethyl-furan-3-carboxylic acid hydrazide

4-iodo-2,5-dimethyl-furan-3-carboxylic acid ethyl ester

2,5-dimethyl-furan-3-carbonyl chloride

Refernces

• 1、 Pace, Domenic P.,Robidas, Rapha?l,Tran, Uyen P. N.,Legault, Claude Y.,Nguyen, Thanh Vinh. "Iodine-Catalyzed Synthesis of Substituted Furans and Pyrans: Reaction Scope and Mechanistic Insights". supporting information. p. 8154 - 8171. Retrieved 2021/06/28.
• 2、 -. "Method for preparing poly-substituted furan compound by condensing tricarbonyl compound under effect of titanium tetrachloride". Paragraph 0064-0066. . Retrieved 2017/11/04.