2-Methoxy-1-naphthaldehyde

Base Information

• Chemical Name: 2-Methoxy-1-naphthaldehyde
• CAS No.: 5392-12-1
• Molecular Formula: C12H10O2
• Molecular Weight: 186.21
• Hs Code.: 29125000
• European Community (EC) Number: 226-392-5
• NSC Number: 28471,3256
• UNII: 7Q7TX7TB9E
• DSSTox Substance ID: DTXSID80202202
• Nikkaji Number: J149.993I
• Wikidata: Q27268710
• ChEMBL ID: CHEMBL3265259
• Mol file: 5392-12-1.mol

Synonyms:2-methoxy-1-naphthaldehyde

Chemical Property of 2-Methoxy-1-naphthaldehyde

Chemical Property:

• Appearance/Colour: beige-brown crystalline powder
• Vapor Pressure: 9.39E-05mmHg at 25°C
• Melting Point: 82-85 °C(lit.)
• Refractive Index: 1.642
• Boiling Point: 339.1 °C at 760 mmHg
• Flash Point: 167.4 °C
• PSA: 26.30000
• Density: 1.169 g/cm³
• LogP: 2.66090
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 186.068079557
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

98% ^*data from raw suppliers

2-Methoxy-1-naphthaldehyde >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=C(C2=CC=CC=C2C=C1)C=O
• Uses: 2-Methoxy-1-naphthaldehyde is a novel strigolactone-signaling inhibitor.

Technology Process of 2-Methoxy-1-naphthaldehyde

There total 32 articles about 2-Methoxy-1-naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methoxy-1-(2-methoxyethenyl)naphthalene (56679-89-1) → 2-methoxy-1-naphthaldehyde (5392-12-1) + (2R,4aR)-2,4a-Dimethoxy-2,4a-dihydro-naphtho[2,1-c][1,2]dioxine (80405-32-9,80405-33-0)

Guidance literature:

With oxygen; 5,15,10,20-tetraphenylporphyrin; In tetrachloromethane; at 5 ℃; for 1h; Irradiation;

DOI:10.1016/S0040-4039(01)81877-3

Reference yield: 95.0%

3-Hydroxy-2-naphthoic acid (92-70-6) + methyl iodide (74-88-4) → 2-methoxy-1-naphthaldehyde (5392-12-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 10h; Cooling with ice;

Reference yield: 92.0%

1,1-diacetoxy-1-(2-methoxynaphth-1-yl)methane → 2-methoxy-1-naphthaldehyde (5392-12-1)

Guidance literature:

With zirconium(IV) chloride; In methanol; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.tet.2003.10.002

upstream raw materials:

hydrogen cyanide

2-Methoxynaphthalene

2,2,2-trichloro-1-(2-methoxy-[1]naphthyl)-ethanol

(2-methoxy-[1]naphthyl)-glyoxylic acid

Downstream raw materials:

2-methoxy-1-methylnaphthalene

(2-methoxy-[1]naphthyl)-pyruvic acid

4-(2-methoxy-5,6-benzobenzylidene)-2-phenyl-5-oxazolone

2-methoxy-1-naphthoic acid

Refernces

• 1、 -. "2, 3-dihydronaphthalo [2, 3-b] furan-4, 9-diketone compound as well as preparation method and application thereof". . . Retrieved 2020/11/05.
• 2、 Betterley, Nolan M.,Kongsriprapan, Sopanat,Chaturonrutsamee, Suppisak,Deelertpaiboon, Pramchai,Surawatanawong, Panida,Pohmakotr, Manat,Soorukram, Darunee,Reutrakul, Vichai,Kuhakarn, Chutima. "Electrophilic Aromatic Formylation with Difluoro(phenylsulfanyl) methane". . p. 2033 - 2040. Retrieved 2018/03/21.