Phenylisoquinoline

Base Information

• Chemical Name: Phenylisoquinoline
• CAS No.: 3297-72-1
• Molecular Formula: C15H11N
• Molecular Weight: 205.259
• Hs Code.: 29334900
• Mol file: 3297-72-1.mol

Synonyms:1-Phenylisoquinoline;

Chemical Property of Phenylisoquinoline

Chemical Property:

• Vapor Pressure: 0.000107mmHg at 25°C
• Melting Point: 96 °C
• Refractive Index: 1.654
• Boiling Point: 347.6 °C at 760 mmHg
• PKA: 4.71±0.30(Predicted)
• Flash Point: 152.2 °C
• PSA: 12.89000
• Density: 1.127 g/cm³
• LogP: 3.90180
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Acetone

Purity/Quality:

99% ^*data from raw suppliers

1-Phenylisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenylisoquinoline

There total 119 articles about Phenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,4-Dichloro-1-phenylisoquinoline (120285-00-9) → 1-phenylisoquinoline (3297-72-1)

Guidance literature:

With ammonia; hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; for 2.5h; under 750.06 Torr; Ambient temperature;

DOI:10.1055/s-1988-27670

Reference yield: 94.0%

1-chloroisoquinoline (19493-44-8) + phenylboronic acid (98-80-6) → 1-phenylisoquinoline (3297-72-1)

Guidance literature:

With 1,3-di-tert-butyl-1,3,2-diazaphospholidine-2-oxide; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 10h;

DOI:10.1002/anie.200462371

Reference yield: 92.0%

1-phenyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline → 1-phenylisoquinoline (3297-72-1)

Guidance literature:

With oxygen; sodium hydroxide; In water; dimethyl sulfoxide; at 125 ℃; for 2h;

DOI:10.1002/ejoc.201001153

upstream raw materials:

isoquinoline

diethyl ether

phenyllithium

nitrobenzene

Downstream raw materials:

1-phenyl-1-p-tolyl-1,2-dihydro-isoquinoline

3-hydroxy-3-phenyl-2,3-dihydro-isoindol-1-one

4-bromo-1-phenylisoquinoline

(+)-1-cyano-1-phenyl-1,2-dihydroisoquinoline-2-carboxylic acid vinyl ester

Refernces

• 1、 Jiang, Jiaxing,Jiang, Changyun,Yang, Wei,Zhen, Hongyu,Huang, Fei,Cao, Yong. "High-efficiency electrophosphorescent fluorene-alt-carbazole copolymers N-grafted with cyclometalated Ir complexes". . p. 4072 - 4080. Retrieved 2005.
• 2、 Wu, Chuan,Tao, Silu,Chen, Mingming,Wong, Fu-Lung,Yuan, Yi,Mo, Hin-Wai,Zhao, Weiming,Lee, Chun-Sing. "Efficient and stable deep-red phosphorescent organic light-emitting diodes based on an iridium complex containing a benzoxazole-substituted ancillary ligand". . p. 2575 - 2578. Retrieved 2013.
• 3、 Shriner,Johnston,Kaslow. "-". . p. 204,206, 207. Retrieved 1949.
• 4、 Martinez, Erin E.,Larson, Alexandra J. S.,Fuller, Sydney K.,Petersen, Kathryn M.,Smith, Stacey J.,Michaelis, David J.. "2-Phosphinoimidazole Ligands: N-H NHC or P-N Coordination Complexes in Palladium-Catalyzed Suzuki-Miyaura Reactions of Aryl Chlorides". supporting information. p. 1560 - 1564. Retrieved 2021/05/29.
• 5、 Liu, Yanpeng,Yu, Tianjun,Zeng, Yi,Chen, Jinping,Yang, Guoqiang,Li, Yi. "Efficient acceptorless dehydrogenation of hydrogen-rich N-heterocycles photocatalyzed by Ni(OH)2@CdSe/CdS quantum dots". . p. 3810 - 3817. Retrieved 2021/06/18.