3-Chloroquinoline

Base Information

• Chemical Name: 3-Chloroquinoline
• CAS No.: 612-59-9
• Molecular Formula: C9H6ClN
• Molecular Weight: 163.606
• Hs Code.: 2933499090
• Mol file: 612-59-9.mol

Synonyms:3-Chloroquinoline;

Chemical Property of 3-Chloroquinoline

Chemical Property:

• Vapor Pressure: 0.0257mmHg at 25°C
• Refractive Index: 1.652
• Boiling Point: 255.7 °C at 760 mmHg
• PKA: 2.56±0.11(Predicted)
• Flash Point: 133.2 °C
• PSA: 12.89000
• Density: 1.27g/cm³
• LogP: 2.88820
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Chloroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloroquinoline

There total 11 articles about 3-Chloroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

chloroform (67-66-3,8013-54-5) + o-toluidine (95-53-4) → quinoline (91-22-5) + indole (120-72-9) + 2-Chloroquinoline (612-62-4) + 3-chloroquinoline (612-59-9)

Guidance literature:

at 550 ℃; Further byproducts given;

Reference yield: 72.0%

C23H16N2O2 (115975-19-4) → 3-chloroquinoline (612-59-9) + benzophenone (119-61-9) + hexachloroethane (67-72-1) + benzophenone azine (983-79-9)

Guidance literature:

With tetrachloromethane; Yields of byproduct given; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(00)82327-8

Reference yield: 56.0%

chloroform (67-66-3,8013-54-5) + N,N-dimethyl-o-toluidine (609-72-3) → quinoline (91-22-5) + 2-methylquinoline (91-63-4) + 8-methylquinoline (611-32-5) + 3-chloroquinoline (612-59-9) + 4-chloro-2-methylquinoline (10222-49-8) + o-toluidine (95-53-4)

Guidance literature:

at 550 ℃; Product distribution; other objects of study: further aniline derivatives and aminoheteroaromatic compounds;

upstream raw materials:

chloroform

N,N-dimethyl-o-toluidine

C₂₃H₁₆N₂O₂

N,N-dimethyl-aniline

Downstream raw materials:

3-chloro-2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxyquinolin-5-amine

3-methylquinoline

quinoline

3-phenoxy-quinoline

Refernces

• 1、 Busby, Reginald E.,Hussain, Syed M.,Mohamed, Murtedza bin,Parrick, John,Shaw, C. J. Granville,et al.. "THE REACTIONS OF HALOGENOMETHANES IN THE VAPOUR PHASE. PART 6. THE ANNELATION OF ANILINE DERIVATIVES AND THE RING-OPENING OF CERTAIN AMINOHETEROAROMATIC COMPOUNDS WITH CHLOROFORM AT 550 deg C.". . p. 4935 - 4953. Retrieved 2007/10/02.