5-Chloro-2-nitropyridine

Base Information

• Chemical Name: 5-Chloro-2-nitropyridine
• CAS No.: 52092-47-4
• Molecular Formula: C5H3ClN2O2
• Molecular Weight: 158.544
• Hs Code.: 2933399090
• European Community (EC) Number: 639-354-1
• NSC Number: 90388
• DSSTox Substance ID: DTXSID90293525
• Nikkaji Number: J1.897.133J
• Wikidata: Q72456027
• Mol file: 52092-47-4.mol

Synonyms:5-Chloro-2-nitropyridine;52092-47-4;2-Nitro-5-chloropyridine;MFCD03092916;Pyridine, 5-chloro-2-nitro-;3-Chloro-6-nitropyridine;5-Chloro-2-nitro-pyridine;NSC90388;Ribociclib Intermediates;NCIOpen2_001326;SCHEMBL851644;SCHEMBL17525875;DTXSID90293525;5-Chloro-2-nitropyridine, 97%;YUBHMOQVHOODEI-UHFFFAOYSA-N;BCP09359;NSC-90388;AKOS000431607;CS-W002991;PS-4114;SB53003;AC-23544;SY013411;A7656;AM20070239;FT-0601489;EN300-08929;5-chloro-2-nitr5-Chloro-2-nitropyridineopyridine;J-517330;Z104475594

Chemical Property of 5-Chloro-2-nitropyridine

Chemical Property:

• Vapor Pressure: 0.00865mmHg at 25°C
• Melting Point: 119-123oC
• Refractive Index: 1.587
• Boiling Point: 275.3 °C at 760 mmHg
• PKA: -4.87±0.22(Predicted)
• Flash Point: 120.3 °C
• PSA: 58.71000
• Density: 1.489 g/cm³
• LogP: 2.16640
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 157.9883050
• Heavy Atom Count: 10
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,N,Xn
• Statements: 20/21/22-36/37/38-50-41-22
• Safety Statements: 26-36/37/39-36-61-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1Cl)[N+](=O)[O-]
• Uses: 5-Chloro-2-nitropyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of 5-Chloro-2-nitropyridine

There total 8 articles about 5-Chloro-2-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-chloro-2-pyridylamine (1072-98-6) → 5-chloro-2-nitropyridine (52092-47-4)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; at 20 ℃; for 48h;

Reference yield: 63.0%

→ 5-chloro-2-nitropyridine (52092-47-4) + N-(5-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-2-pyridinyl)-2-fluorobenzamide

Guidance literature:

Reference yield: 38.0%

2-dimethylsulfilimino-5-chloropyridine (134251-85-7) → 5-chloro-2-nitropyridine (52092-47-4) + 5-Chloro-2-nitro-pyridine 1-oxide (134251-87-9)

Guidance literature:

With dihydrogen peroxide; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1007/BF00476986

upstream raw materials:

5-chloro-2-pyridylamine

(3-chloro-6-nitro-[2]pyridyl)-hydrazine

2-dimethylsulfilimino-5-chloropyridine

3-hydroxy-2-nitropyridine

Downstream raw materials:

5-(4-chloro-phenylsulfanyl)-2-nitro-pyridine

(S)-N-(1-cyclohexylethyl)-6-(6-nitropyridin-3-yloxy)benzo[d]thiazol-2-amine

2-nitro-5-phenylpyridine

benzyl {2-fluoro-4-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate

Refernces

• 1、 -. "INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL". Page/Page column 65. . Retrieved 2015/07/15.
• 2、 -. "INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL". Page/Page column 56. . Retrieved 2013/03/28.