3-DI-N-PROPYLAMINO-1-PROPYNE

Base Information

• Chemical Name: 3-DI-N-PROPYLAMINO-1-PROPYNE
• CAS No.: 6323-79-1
• Molecular Formula: C9H17 N
• Molecular Weight: 139.241
• Hs Code.: 2921199090
• Mol file: 6323-79-1.mol

Synonyms:2-Propynylamine,N,N-dipropyl- (7CI,8CI); 1-(Dipropylamino)-2-propyne; 3-(Dipropylamino)propyne;Dipropylpropargylamine; NSC 34156; Propargyldipropylamine

Chemical Property of 3-DI-N-PROPYLAMINO-1-PROPYNE

Chemical Property:

• Vapor Pressure: 0.818mmHg at 25°C
• Refractive Index: 1.4350
• Boiling Point: 157-159°C
• Flash Point: 157-159°C
• PSA: 3.24000
• Density: 0,799 g/cm3
• LogP: 1.74160

Purity/Quality:

99% ^*data from raw suppliers

3-Di-N-propylamino-1-propyne ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-DI-N-PROPYLAMINO-1-PROPYNE

There total 2 articles about 3-DI-N-PROPYLAMINO-1-PROPYNE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

di-n-propylamine (142-84-7) + propargyl bromide (106-96-7) → N,N-dipropylprop-2-yn-1-amine (6323-79-1)

Guidance literature:

With caesium carbonate; In acetone; at 20 ℃;

DOI:10.1021/jm0005555

Reference yield:

→ N,N-dipropylprop-2-yn-1-amine (6323-79-1)

Guidance literature:

With ammonia; sodium amide;

DOI:10.1021/ja01163a600

Reference yield: 94.0%

N,N-dipropylprop-2-yn-1-amine (6323-79-1) + 1-bromo-4-tert-butylbenzene (3972-65-4) → 1-(4-tert-butylphenyl)-3-(dipropylamino)propyne

Guidance literature:

With copper(l) iodide; potassium carbonate; (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis((diphenylphosphanyl)methyl)cyclopentane; bis(η3-allyl-μ-chloropalladium(II)); In N,N-dimethyl-formamide; at 130 ℃; for 20h;

DOI:10.1055/s-2005-865284

upstream raw materials:

di-n-propylamine

propargyl bromide

Downstream raw materials:

pent-2-ynyl-dipropyl-amine

hex-2-ynyl-dipropyl-amine

but-2-ynyl-dipropyl-amine

1,2-propanediene

Refernces

• 1、 Tsou,Mamuya,Johnson,Reich,Gruber,Ye,Nilakantan,Shen,Discafani,DeBlanc,Davis,Koehn,Greenberger,Wang,Wissner. "6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity". . p. 2719 - 2734. Retrieved 2007/10/03.