2-Phenylpyrazolo(1,5-a)quinoline

Base Information

• Chemical Name: 2-Phenylpyrazolo(1,5-a)quinoline
• CAS No.: 56983-96-1
• Molecular Formula: C17H12 N2
• Molecular Weight: 244.296
• Mol file: 56983-96-1.mol

Synonyms:2-Phenylpyrazolo[1,5-a]quinoline

Chemical Property of 2-Phenylpyrazolo(1,5-a)quinoline

Chemical Property:

• Vapor Pressure: 0.00195mmHg at 25°C
• Boiling Point: 291.5°Cat760mmHg
• Flash Point: 130.1°C
• PSA: 17.30000
• Density: 1.17g/cm³
• LogP: 4.15450

Purity/Quality:

2-PHENYLPYRAZOLO(1,5-A)QUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenylpyrazolo(1,5-a)quinoline

There total 24 articles about 2-Phenylpyrazolo(1,5-a)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C11H7BrN2 + phenylboronic acid (98-80-6) → 2-phenylpyrazolo<1,5-a>quinoline (56983-96-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; for 6h; Reflux;

Reference yield: 90.0%

(benzoyl)(quinolin-1-ium-1-yl)amide + E-styryl iodide (42599-24-6) → 2-phenylpyrazolo<1,5-a>quinoline (56983-96-1)

Guidance literature:

With P(p-CH₃OC₆H₄)3; silver benzoate; palladium(II) bromide; In 1,4-dioxane; at 125 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol902710f

Reference yield: 90.0%

ethyl 2-phenylpyrazolo[1,5-a]quinoline-3-carboxylate (63237-80-9) → 2-phenylpyrazolo<1,5-a>quinoline (56983-96-1)

Guidance literature:

With hydrogen iodide; for 3h; Heating;

upstream raw materials:

2-phenylethynylquinoline

syn-(E)-2-(2-Chinolyl)-1-phenylethanonoxim

2,4,6-Trimethyl-benzenesulfonate1-amino-2-phenylethynyl-quinolinium;

4,5-dihydro-2-phenylpyrazolo<1,5-a>quinolin-3-carboxylic acid

Refernces

• 1、 Mousseau, James J.,Bull, James A.,Ladd, Carolyn L.,Fortier, Angelique,Sustac Roman, Daniela,Charette, Andre B.. "Synthesis of 2- and 2,3-substituted Pyrazolo[1,5- a ]pyridines: Scope and mechanistic considerations of a domino direct alkynylation and cyclization of n -iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes". experimental part. p. 8243 - 8261. Retrieved 2012/01/03.
• 2、 Winters,Odasso,Conti,et al.. "Synthesis and pregnancy terminating activity of pyrazolo[1,5-a]indoles and quinolines". . p. 215 - 218. Retrieved 2007/10/02.