D-Glucono-1,4-lactone

Base Information

• Chemical Name: D-Glucono-1,4-lactone
• CAS No.: 1198-69-2
• Molecular Formula: C6H10O6
• Molecular Weight: 178.142
• Hs Code.: 2932209090
• UNII: F62S8J9R28
• DSSTox Substance ID: DTXSID301316621
• Nikkaji Number: J576.460B
• Wikidata: Q27098411
• Metabolomics Workbench ID: 50405
• Mol file: 1198-69-2.mol

Synonyms:D-glucono-1,4-lactone;glucono-1,4-lactone

Chemical Property of D-Glucono-1,4-lactone

Chemical Property:

• Vapor Pressure: 1.01E-10mmHg at 25°C
• Melting Point: 134-135 °C
• Refractive Index: 1.625
• Boiling Point: 467.9 °C at 760 mmHg
• PKA: 12.06±0.60(Predicted)
• Flash Point: 201.5 °C
• PSA: 107.22000
• Density: 1.766 g/cm³
• LogP: -3.01320
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Sparingly), Methanol (Slightly), Water (Sparingly)
• XLogP3: -2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 178.04773803
• Heavy Atom Count: 12
• Complexity: 181

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-Glucono-1,4-lactone(>85%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C1C(C(C(=O)O1)O)O)O)O
• Isomeric SMILES: C([C@H]([C@@H]1[C@@H]([C@H](C(=O)O1)O)O)O)O
• Uses: D-Glucono-1,4-lactone was a metabolite studied in mice tissue with induced chronic stress.

Technology Process of D-Glucono-1,4-lactone

There total 24 articles about D-Glucono-1,4-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

C18H42O6Si4 → D-glucono-1,4-lactone (1198-69-2)

Guidance literature:

With potassium fluoride; In methanol; at 20 ℃; for 5.25h; Temperature; Reagent/catalyst; Inert atmosphere;

Reference yield: 90.0%

D-Glucose (2280-44-6) → D-glucono-1,4-lactone (1198-69-2)

Guidance literature:

With rhodium hydrido (PEt₃)3 complex; 1-Phenylbut-1-en-3-one; In N,N-dimethyl-formamide; at 40 ℃; for 4h;

DOI:10.1016/0040-4039(94)02262-A

Reference yield: 64.0%

D-Glucono-1,5-lactone (90-80-2,1335-57-5,4253-68-3) → D-glucono-1,4-lactone (1198-69-2)

Guidance literature:

With hydrogenchloride; acetic acid; In methanol; for 0.0333333h; microwave irradiation;

DOI:10.1080/07328300701540258

upstream raw materials:

gluconic acid

D-Glucono-1,5-lactone

D-Glucose

methanol

Downstream raw materials:

D-arabino-[2]hexulosonic acid methyl ester

N-phenyl-D-gluconamide

D-sorbitol

D-idono-1,4-lactone

Refernces

• 1、 Araki,Hashi. "-". . . Retrieved 1942.
• 2、 Isaac, Isabelle,Stasik, Imane,Beaupere, Daniel,Uzan, Raoul. "A NEW AND DIRECT ACCESS TO GLYCONO-1,4-LACTONES FROM GLYCOPYRANOSES BY REGIOSELECTIVE OXIDATION AND SUBSEQUENT RING RESTRICTION". . p. 383 - 386. Retrieved 1995.
• 3、 -. "Preparation method of D-gluconic acid-gamma-lactone and intermediate thereof". Paragraph 0047-0065; 0069-0070; 0075. . Retrieved 2020/02/17.