8-HYDROXYQUINOLINE-7-CARBOXYLIC ACID

Base Information

• Chemical Name: 8-HYDROXYQUINOLINE-7-CARBOXYLIC ACID
• CAS No.: 19829-79-9
• Molecular Formula: C10H7 N O3
• Molecular Weight: 189.17
• Hs Code.: 2933499090
• Mol file: 19829-79-9.mol

Synonyms:7-Carboxy-8-hydroxyquinoline;7-Isoquinolinecarboxylic acid, 8-hydroxy-; 8-Hydroxy-7-quinolinecarboxylicacid; NSC 27445; NSC 35082

Chemical Property of 8-HYDROXYQUINOLINE-7-CARBOXYLIC ACID

Chemical Property:

• Melting Point: 208-209 °C (decomp)
• Boiling Point: 384.7°Cat760mmHg
• PKA: 1.34±0.30(Predicted)
• Flash Point: 186.5°C
• PSA: 70.42000
• Density: 1.48g/cm³
• LogP: 1.63860
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

8-Hydroxyquinoline-7-carboxylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 8-Hydroxyquinoline-7-carboxylic Acid can be used for small molecule therapeutic agent compounds.

Technology Process of 8-HYDROXYQUINOLINE-7-CARBOXYLIC ACID

There total 5 articles about 8-HYDROXYQUINOLINE-7-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.6%

carbon dioxide (124-38-9,18923-20-1) + potassium quinolin-8-olate (37407-37-7) → 8-hydroxy-7-quinolinecarboxylic acid (19829-79-9)

Guidance literature:

at 200 ℃; for 8h; under 15001.2 Torr;

Reference yield: 38.0%

8-quinolinol (148-24-3,24804-14-6) + carbon dioxide (124-38-9,18923-20-1) → 8-hydroxy-7-quinolinecarboxylic acid (19829-79-9)

Guidance literature:

8-quinolinol; With potassium tert-butylate; In tetrahydrofuran; for 1h; Reflux;

carbon dioxide; In N,N-dimethyl-formamide; at 115 - 120 ℃; for 3h;

DOI:10.1016/j.molstruc.2012.08.009

Reference yield: 30.4%

potassium quinolin-8-olate (37407-37-7) → 8-hydroxy-7-quinolinecarboxylic acid (19829-79-9)

Guidance literature:

In water; N,N-dimethyl-formamide;

upstream raw materials:

8-quinolinol

carbon dioxide

potassium quinolin-8-olate

Downstream raw materials:

8-quinolinol

8-benzyloxyquinoline-7-carboxylic acid benzyl ester

broxyquinoline

N-(4-chlorobenzyl)-8-hydroxyquinoline-7-carboxamide

Refernces

• 1、 Nycz, Jacek E.,Malecki, Grzegorz J.. "Synthesis, spectroscopy and computational studies of selected hydroxyquinoline carboxylic acids and their selected fluoro-, thio-, and dithioanalogues". . p. 159 - 168. Retrieved 2013/02/22.
• 2、 Caris,Baret,Pierre,Serratrice. "Synthesis and NMR study of two lipophilic iron(III) sequestering agents based on 8-hydroxyquinoline; H-bonding and conformationsl changes". . p. 4659 - 4672. Retrieved 2007/10/03.