Technology Process of Desmethylcitalopram
There total 9 articles about Desmethylcitalopram which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(3-dimethylamino-propyl)-1-(4-fluoro-phenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile;
With
carbonochloridic acid 1-chloro-ethyl ester;
In
dichloromethane; toluene;
at 10 - 20 ℃;
Industry scale;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane; toluene;
at 20 - 65 ℃;
Industry scale;
- Guidance literature:
-
citalopram hydrobromide;
With
ammonium hydroxide;
In
water;
With
carbonochloridic acid 1-chloro-ethyl ester;
In
1,2-dichloro-ethane;
at 0 ℃;
for 18h;
Inert atmosphere;
Reflux;
DOI:10.1021/ml5000806
- Guidance literature:
-
citalopram hydrobromide;
With
carbonochloridic acid 1-chloro-ethyl ester;
In
methanol;
at 65 - 130 ℃;
for 11h;
With
sodium hydroxide;
In
tetrahydrofuran;
at 25 ℃;
for 14h;
