2-FLUORO-5-METHYLPHENOL

Base Information

• Chemical Name: 2-FLUORO-5-METHYLPHENOL
• CAS No.: 63762-79-8
• Molecular Formula: C7H7 F O
• Molecular Weight: 126.13
• Hs Code.: 2908199090
• Mol file: 63762-79-8.mol

Synonyms:2-Fluoro-5-methylphenol;4-Fluoro-3-hydroxytoluene; 6-Fluoro-m-cresol

Chemical Property of 2-FLUORO-5-METHYLPHENOL

Chemical Property:

• Appearance/Colour: COLORLESS TO YELLOW LIQUID
• Vapor Pressure: 0.00138mmHg at 25°C
• Melting Point: 32 °C
• Refractive Index: n20/D 1.511(lit.)
• Boiling Point: 175 °C at 760 mmHg
• PKA: 8.82±0.10(Predicted)
• Flash Point: 68.1 °C
• PSA: 20.23000
• Density: 1.164 g/cm³
• LogP: 1.83970
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.5% ^*data from raw suppliers

2-Fluoro-5-methylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-21/22
• Safety Statements: 26-36-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Fluoro-5-methylphenol may be employed as additive in various alkyne metatheses.

Technology Process of 2-FLUORO-5-METHYLPHENOL

There total 9 articles about 2-FLUORO-5-METHYLPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(2-fluoro-5-methylphenoxy)pyridine → 2-fluoro-5-methylphenol (63762-79-8)

Guidance literature:

2-(2-fluoro-5-methylphenoxy)pyridine; With methyl trifluoromethanesulfonate; In toluene; at 100 ℃; for 2h; Inert atmosphere;

With sodium ethanolate; for 1h; Reflux; Inert atmosphere;

Reference yield: 76.0%

3-methyl-phenol (108-39-4) → 2-fluoro-5-methylphenol (63762-79-8)

Guidance literature:

With acetic acid; Selectfluor; eosin y; In water; at 20 ℃; for 6h; Irradiation; Green chemistry;

Reference yield: 23.7%

3-methyl-phenol (108-39-4) → 4-fluoro-3-methylphenol (452-70-0) + 2-fluoro-5-methylphenol (63762-79-8) + 2-fluoro-3-methylphenol (77772-72-6)

Guidance literature:

With fluorine; In various solvent(s); at 0 ℃; for 2h;

DOI:10.1016/S0022-1139(00)85261-6

upstream raw materials:

3-amino-4-fluorotoluene

3-methyl-phenol

2-methoxy-4-methylaniline

3-methoxy-4-nitrotoluene

Downstream raw materials:

4-methoxy-5-allyl-6-methyl-3-fluoro-bromobenzene

C₁₃H₁₀BrFO

3-(2-fluoro-5-methyl-phenoxy)-but-2-enoic acid ethyl ester

C₁₃H₁₇FO₃

Refernces

• 1、 -. "Synthesis of 2 - fluoro phenol compounds". . . Retrieved 2017/04/21.
• 2、 Singh, Sukhjinder,DesMarteau, Darryl D.,Zuberi, Sharique S.,Witz, Michael,Huang, Hsu-Nan. "N-Fluoroperfluoroalkylsulfonimides. Remarkable New Fluorination Reagents". . p. 7194 - 7196. Retrieved 2007/10/02.