1-TOSYLPYRAZOLE

Base Information

• Chemical Name: 1-TOSYLPYRAZOLE
• CAS No.: 6126-10-9
• Molecular Formula: C10H10 N2 O2 S
• Molecular Weight: 222.268
• Hs Code.: 2933199090
• Mol file: 6126-10-9.mol

Synonyms:Pyrazole,1-(p-tolylsulfonyl)- (7CI,8CI); 1-(p-Toluenesulfonyl)pyrazole; 1-Tosylpyrazole;1-[(4-Methylphenyl)sulfonyl]-1H-pyrazole; NSC 269428

Chemical Property of 1-TOSYLPYRAZOLE

Chemical Property:

• Vapor Pressure: 2.53E-06mmHg at 25°C
• Boiling Point: 391.1°C at 760 mmHg
• Flash Point: 190.3°C
• PSA: 60.34000
• Density: 1.29g/cm³
• LogP: 2.50930
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Tosyl-1H-pyrazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-TOSYLPYRAZOLE

There total 7 articles about 1-TOSYLPYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

NH-pyrazole (288-13-1) + p-toluenesulfonyl chloride (98-59-9) → 1-(4-toluenesulfonyl)-1H-pyrazole (6126-10-9)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1002/adsc.201301139

Reference yield: 78.0%

NH-pyrazole (288-13-1) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 1-(4-toluenesulfonyl)-1H-pyrazole (6126-10-9)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In decane; 1,2-dichloro-ethane; at 20 ℃; for 1h;

DOI:10.1039/c5ob02075a

Reference yield: 46.0%

NH-pyrazole (288-13-1) + sodium 4-methylbenzenesulfinate (824-79-3) → 1-(4-toluenesulfonyl)-1H-pyrazole (6126-10-9)

Guidance literature:

With sodium percarbonate; iodine; In cis-1,2-Dichloroethylene; acetonitrile; at 40 ℃; for 24h;

DOI:10.1002/ejoc.201403531

upstream raw materials:

NH-pyrazole

4-nitrophenyl 4-methylbenzenesulfonate

p-toluenesulfonyl chloride

sodium 4-methylbenzenesulfinate

Downstream raw materials:

2-ethyl-1-{1-[(4-methylphenyl)sulfonyl]-1H-pyrazol-5-yl}butan-1-ol

5-iodo-1-[(4-methylphenyl) sulfonyl]-1H-pyrazole

Refernces

• 1、 Buathongjan, Chonchanok,Beukeaw, Danupat,Yotphan, Sirilata. "Iodine-catalyzed oxidative amination of sodium sulfinates: A convenient approach to the synthesis of sulfonamides under mild conditions". . p. 1575 - 1582. Retrieved 2015/03/04.
• 2、 Kumpulainen, Esa T. T.,Pohjakallio, Antti. "Selective palladium-catalyzed direct C-H arylation of unsubstituted N-protected pyrazoles". supporting information. p. 1555 - 1561. Retrieved 2014/06/09.