DIMETHYL A-BROMOGLUTARATE

Base Information

• Chemical Name: DIMETHYL A-BROMOGLUTARATE
• CAS No.: 760-94-1
• Molecular Formula: C7H11 Br O4
• Molecular Weight: 239.066
• Hs Code.: 2917190090
• Mol file: 760-94-1.mol

Synonyms:Glutaricacid, 2-bromo-, dimethyl ester (7CI,8CI); Pentanedioic acid, 2-bromo-, dimethylester (9CI); Dimethyl 2-bromoglutarate; Dimethyl 2-bromopentanedioate; Dimethyla-bromoglutarate

Chemical Property of DIMETHYL A-BROMOGLUTARATE

Chemical Property:

• Vapor Pressure: 0.0382mmHg at 25°C
• Refractive Index: 1.4631 (589.3 nm 20℃)
• Boiling Point: 135℃ (11 Torr)
• Flash Point: 99.1±23.2℃
• PSA: 52.60000
• Density: 1.452±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 0.87610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Dimethyl2-bromopentanedioate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIMETHYL A-BROMOGLUTARATE

There total 1 articles about DIMETHYL A-BROMOGLUTARATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + methyl 4-(chlorocarbonyl)butyrate (1501-26-4) → Dimethyl glutarate (1119-40-0) + dimethyl-2-bromoglutarate (760-94-1)

Guidance literature:

With bromine; Yield given. Multistep reaction; 1.) RT, 12 h, 2.) 0 deg C, 3 h;

DOI:10.1021/jo00142a028

Reference yield: 97.0%

dimethyl-2-bromoglutarate (760-94-1) + 4-hydroxy-2-methyl-1-(phenylmethyl)-1H-indole (172732-78-4) → 2-(1-Benzyl-2-methyl-1H-indol-4-yloxy)-pentanedioic acid 1-methyl ester 5-methyl ester (936567-78-1)

Guidance literature:

4-hydroxy-2-methyl-1-(phenylmethyl)-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

dimethyl-2-bromoglutarate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield: 90.0%

dimethyl-2-bromoglutarate (760-94-1) + sodium thiophenolate (930-69-8) → phenylthio-2 glutarate de methyle (82111-66-8)

Guidance literature:

In methanol; for 1h; Heating;

DOI:10.1021/jo00142a028

upstream raw materials:

methanol

methyl 4-(chlorocarbonyl)butyrate

Downstream raw materials:

phenylthio-2 glutarate de methyle

1-benzyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

5-(hydroxymethyl)-1-(4-methoxyphenyl)pyrrolidin-2-one

(RS)-5-iodomethyl-1-(4-methoxyphenyl)pyrrolidin-2-one

Refernces