ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE
• CAS No.: 86129-63-7
• Molecular Formula: C9H9Cl2NO2
• Molecular Weight: 234.082
• Hs Code.: 2933399090
• Mol file: 86129-63-7.mol

Synonyms:2,4-Dichloro-6-methylnicotinicacid ethyl ester;Ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate;Ethyl ester,2,4-dichloro-6-methyl-3-pyridinecarboxylic acid;

Chemical Property of ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE

Chemical Property:

• Appearance/Colour: Solid
• Vapor Pressure: 0.00129mmHg at 25°C
• Melting Point: 53 °C
• Refractive Index: 1.537
• Boiling Point: 298.2 °C at 760 mmHg
• PKA: -0.22±0.10(Predicted)
• Flash Point: 134.1 °C
• PSA: 39.19000
• Density: 1.32 g/cm³
• LogP: 2.87350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl2,4-Dichloro-6-methylnicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE

There total 6 articles about ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate (10350-10-4) → ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (86129-63-7)

Guidance literature:

With trichlorophosphate; at 140 ℃; for 4h;

DOI:10.1055/s-1988-27614

Reference yield: 55.0%

ethyl 2,4-dihydroxy-6-methylnicotinate (10350-10-4,70254-52-3,70254-53-4) → ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (86129-63-7)

Guidance literature:

ethyl 2,4-dihydroxy-6-methylnicotinate; With 1-[N,N-bis(2-hydroxyethyl)amino]-2-propanol; trichlorophosphate; at 0 - 25 ℃; for 20h;

With sodium carbonate; In water; at 0 ℃; pH=8;

Reference yield: 38.0%

ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate (10350-10-4) → ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (86129-63-7) + ethyl 1,2-dihydro-2-oxo-4-chloro-6-methylpyridine-3-carboxylate (86129-62-6)

Guidance literature:

With trichlorophosphate; for 1h; Heating;

DOI:10.1021/jm00363a022

upstream raw materials:

ethyl 2,4-dihydroxy-6-methylnicotinate

ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate

diethyl malonate

Downstream raw materials:

2,4-Dichloro-3-hydroxymethyl-6-methylpyridine

6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Ethyl 4-ethoxy-6-methylpyridine-3-carboxylate

6-methylnicotinic acid

Refernces

• 1、 Stadlbauer, Wolfgang,Fiala, Werner,Fischer, Michaela,Hojas, Gerhard. "Thermal Cyclization of 3-Acyl-4-azidopyridines to Isoxazolo[4,3-c]pyridines". . p. 33 - 39. Retrieved 2007/10/03.
• 2、 Croisy-Delcey, Martine,Bisagni, Emile. "Aza Analogues of Lucanthone: Synthesis and Antitumor and Bactericidal Properties". . p. 1329 - 1333. Retrieved 2007/10/02.