Oleuropein

Base Information

• Chemical Name: Oleuropein
• CAS No.: 32619-42-4
• Deprecated CAS: 1392-73-0,4809-64-7,30675-34-4,37341-33-6,163436-64-4
• Molecular Formula: C25H34O13
• Molecular Weight: 540.521
• Hs Code.: 29389090
• European Community (EC) Number: 251-129-6
• UNII: 2O4553545L
• ChEMBL ID: CHEMBL1911053
• DSSTox Substance ID: DTXSID60905103
• Nikkaji Number: J17.724E,J420.869B
• Wikidata: Q402625
• Wikipedia: Oleuropein
• Mol file: 32619-42-4.mol

Synonyms:2-(3,4-dihydroxyphenyl)ethyl (2S-(2alpha,3E,4beta))-3-ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate;oleoeuropein;oleoeuropeine;oleuropein

Chemical Property of Oleuropein

Chemical Property:

• Appearance/Colour: brown powder
• Vapor Pressure: 3.93E-25mmHg at 25°C
• Melting Point: 89-90 °C
• Refractive Index: 1.629
• Boiling Point: 772.9 °C at 760 mmHg
• PKA: 9.70±0.10(Predicted)
• Flash Point: 257 °C
• PSA: 201.67000
• Density: 1.5 g/cm³
• LogP: -0.63420
• Storage Temp.: room temp
• Solubility.: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 11
• Exact Mass: 540.18429107
• Heavy Atom Count: 38
• Complexity: 873

Purity/Quality:

98% ^*data from raw suppliers

Oleuropein ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC=C1C(C(=COC1OC2C(C(C(C(O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O
• Isomeric SMILES: C/C=C/1\[C@@H](C(=CO[C@H]1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O
• Description: Oleuropein is a phenolic compound extracted from olive (Canarium album (Lour.) Raeusch., Gan Lan) leaves mainly. The olive tree belongs to family Oleaceae Olea genus of evergreen trees, and it is the world famous fruit and woody species. There is highly edible value for cultivating trees. Affiliated to famous economic forest and subtropical fruit trees, they are rich in olive oil which is considered as high-quality edible oil .
• Physical properties: Appearance: crystal in ethyl acetate. Solubility: very soluble in ethanol, acetone, glacial acetic acid, and 5% NaOH solution; soluble in water, butanol, ethyl acetate, and butyl acetate; insoluble in ether, petroleum ether, chloroform, and carbon tetrachloride. Melting point: 87–89 °C. Specific optical rotation: ?147° in water/ethanol/ propane with a concentration of 1 mol/L; able to convert to ?127° in water in 9 h.
• Uses: Oleuropein is a tyrosol ester derivative of elenolic acid and phenolic glycoside found in olive oil. Oleuropein shows antioxidant, anti-ischemic and hypolipidemic activity. Oleuropein has also been used as an immunomodulator . Oleuropein is a tyrosol ester derivative of elenolic acid and phenolic glycoside found in olive oil. Oleuropein shows antioxidant, anti-ischemic and hypolipidemic activity. Oleuropein has also been us ed as an immunomodulator . olive leaf extract is astringent and anti-septic. It also has vasodialating capacities, as well as being perfuming and skin-conditioning. olive leaf extract has demonstrated some anti-oxidant and freeradical scavenger activities. olive leaves contain both bioflavonoids and polyphenols. The extract generally found in anti-aging products.
• Clinical Use: In the United States and other European countries, olive leaf extract serves as a dietary supplement, and its recommended dose is 50–100 mg as an immunomodulator. FDA also approves olive leaf extracts to be used as antioxidants in foods. In addition, 80% of oleuropein are used for skin care products mainly, and it can protect skin cells from UV. At the same time, it maintains soft and elastic skin effectively to protect skin. With light color and high content, oleuropein is very suitable for cosmetic formula design. In the cream and liquid formula, it is added at a concentration of 0.5–1%. The other pharmacological effects are still in preclinical study.