6-fluoro-8-nitroquinoline

Base Information

• Chemical Name: 6-fluoro-8-nitroquinoline
• CAS No.: 343-26-0
• Molecular Formula: C₉H₅FN₂O₂
• Molecular Weight: 192.149
• Hs Code.: 2933499090
• Mol file: 343-26-0.mol

Synonyms:6-fluoro-8-nitroquinoline

Chemical Property of 6-fluoro-8-nitroquinoline

Chemical Property:

• Vapor Pressure: 0.000396mmHg at 25°C
• Boiling Point: 327°Cat760mmHg
• Flash Point: 151.6°C
• PSA: 58.71000
• Density: 1.446g/cm³
• LogP: 2.80530

Purity/Quality:

98%min ^*data from raw suppliers

6-Fluoro-8-nitroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Fluoro-8-nitroquinoline is an intermediate in synthesizing 6-Fluoro-8-Quinolinesulfonyl Chloride (F596550), which is may act as a clastogenic compound as well as inhibitor of CYP enzymes due to the quinoline moiety in the substructure.

Technology Process of 6-fluoro-8-nitroquinoline

There total 8 articles about 6-fluoro-8-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-nitro-4-fluoroaniline (364-78-3) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 6-fluoro-8-nitroquinoline (343-26-0)

Guidance literature:

2-nitro-4-fluoroaniline; glycerol; With sodium iodide; at 20 ℃; for 0.0833333h;

With sulfuric acid; for 0.166667h; Cooling with ice;

at 140 ℃; for 2h;

DOI:10.1021/acs.joc.9b00942

Reference yield: 11.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 2-nitro-4-fluoroaniline (364-78-3) → 6-fluoro-8-nitroquinoline (343-26-0)

Guidance literature:

With sulfuric acid; In glycerol; at 130 ℃; for 4h;

Reference yield:

6-fluoroquinoline (396-30-5) → 6-fluoro-8-nitroquinoline (343-26-0)

Guidance literature:

With nitric acid;

DOI:10.1021/jo50003a017

upstream raw materials:

6-fluoroquinoline

2-nitro-4-fluoroaniline

glycerol

4-Fluoroquinoline

Downstream raw materials:

8-amino-6-fluoroquinoline

3-bromo-6-fluoro-8-nitroquinoline

8-amino-3-chloro-6-fluoroquinoline

8-amino-3-bromo-6-fluoroquinoline

Refernces

• 1、 -. "THERAPEUTIC COMPOUNDS AND COMPOSITIONS". Page/Page column 180. . Retrieved 2014/09/29.
• 2、 -. "THERAPEUTIC COMPOUNDS AND COMPOSITIONS". Page/Page column 193; 194. . Retrieved 2014/09/29.