N-cyclohexylpentanamide

Base Information

• Chemical Name: N-cyclohexylpentanamide
• CAS No.: 2763-66-8
• Molecular Formula: C11H21NO
• Molecular Weight: 183.294
• Hs Code.: 2924299090
• NSC Number: 133410
• DSSTox Substance ID: DTXSID60299877
• Wikidata: Q82042568
• Mol file: 2763-66-8.mol

Synonyms:N-cyclohexylpentanamide;2763-66-8;Pentanamide, N-cyclohexyl;N-5-Chlorovaleryl cyclohexylamine;NSC133410;SCHEMBL7494872;DTXSID60299877;N-cyclohexyl-pentanoic acid amide;JDGRQVUDURNFLX-UHFFFAOYSA-N;AKOS003853922;NSC-133410;AC-13663;AO-548/06842022;J-016830;Z54739725

Chemical Property of N-cyclohexylpentanamide

Chemical Property:

• Vapor Pressure: 0.000145mmHg at 25°C
• Refractive Index: 1.466
• Boiling Point: 332.6 °C at 760 mmHg
• Flash Point: 198 °C
• PSA: 29.10000
• Density: 0.92 g/cm³
• LogP: 3.01640
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 183.162314293
• Heavy Atom Count: 13
• Complexity: 150

Purity/Quality:

99% ^*data from raw suppliers

N-CYCLOHEXYLPENTANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(=O)NC1CCCCC1

Technology Process of N-cyclohexylpentanamide

There total 11 articles about N-cyclohexylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-(4-chlorophenyl)-N-pentanoyl-4-nitrobenzenesulfonamide + cyclohexylamine (108-91-8,157973-60-9) → N‐cyclohexylpentanamide (2763-66-8) + N-(4-chlorophenyl)-4-nitrobenzenesulfonamide (16937-03-4)

Guidance literature:

With potassium carbonate; In water; at 80 ℃; for 0.166667h; Green chemistry;

DOI:10.1515/znb-2015-0076

Reference yield: 71.0%

cyclohexylamine (108-91-8,157973-60-9) + n-valeryl chloride (638-29-9) → N‐cyclohexylpentanamide (2763-66-8)

Guidance literature:

With potassium carbonate; In dichloromethane; at 30 ℃; for 5h;

DOI:10.1002/anie.201706963

Reference yield: 61.0%

diethyl 2,6‐dimethyl‐1‐pentanamido‐1,4‐dihydropyridine‐3,5‐dicarboxylate + cyclohexene (110-83-8) → N‐cyclohexylpentanamide (2763-66-8)

Guidance literature:

With rhodamine 6G; thiophenol; In dichloromethane; at 20 ℃; regioselective reaction; Sealed tube; Irradiation;

DOI:10.1002/ejoc.202100049

upstream raw materials:

valeric acid hydrazide

cyclohexylamine

n-valeryl chloride

N-cyclohexyl-cyclohexanamine

Refernces

• 1、 Li, Xinwei,Lin, Fengguirong,Huang, Kaimeng,Wei, Jialiang,Li, Xinyao,Wang, Xiaoyang,Geng, Xiaoyu,Jiao, Ning. "Selective α-Oxyamination and Hydroxylation of Aliphatic Amides". supporting information. p. 12307 - 12311. Retrieved 2017/09/11.
• 2、 Zhou, Jiadi,Jin, Can,Li, Xiaohan,Su, Weike. "Copper-catalyzed oxidative esterification of unactivated C(sp3)-H bonds with carboxylic acids via cross dehydrogenative coupling". . p. 7232 - 7236. Retrieved 2015/03/03.