1,3-Bis(p-methoxyphenyl)urea

Base Information

• Chemical Name: 1,3-Bis(p-methoxyphenyl)urea
• CAS No.: 1227-44-7
• Molecular Formula: C15H16 N2 O3
• Molecular Weight: 272.304
• Hs Code.: 2924299090
• Mol file: 1227-44-7.mol

Synonyms:Carbanilide,4,4'-dimethoxy- (6CI,7CI,8CI); Carbanilide, p,p'-dimethoxy- (3CI);1,3-Bis(4-methoxyphenyl)urea; 1,3-Bis(p-methoxyphenyl)urea;4,4'-Dimethoxycarbanilide; N,N'-Bis(4-methoxyphenyl)urea;N,N'-Bis(p-methoxyphenyl)urea; N,N'-Di-p-anisylurea; NSC 24700; NSC 28782

Chemical Property of 1,3-Bis(p-methoxyphenyl)urea

Chemical Property:

• Vapor Pressure: 7.51E-05mmHg at 25°C
• Melting Point: 239.0 to 243.0 °C
• Boiling Point: 342.5°C at 760 mmHg
• Flash Point: 160.9°C
• PSA: 59.59000
• Density: 1.249g/cm³
• LogP: 3.49380

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,3-Bis(4-methoxyphenyl)urea ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1,3-Bis(p-methoxyphenyl)urea

There total 91 articles about 1,3-Bis(p-methoxyphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-methoxy-aniline (104-94-9) + urea (57-13-6) → N,N'-bis(4-methoxyphenyl)urea (1227-44-7)

Guidance literature:

With zinc(II) chloride; at 80 ℃; for 0.0833333h; Neat (no solvent);

DOI:10.1080/00397910802697467

Reference yield: 98.0%

carbon monoxide (201230-82-2) + 4-methoxy-aniline (104-94-9) → N,N'-bis(4-methoxyphenyl)urea (1227-44-7)

Guidance literature:

With carbon dioxide; oxygen; potassium iodide; palladium(II) iodide; In 1,2-dimethoxyethane; at 100 ℃; for 15h; under 45600 Torr;

DOI:10.1021/jo0494634

Reference yield: 97.0%

4-methoxy-aniline (104-94-9) + 4-Methoxyphenyl isocyanate (5416-93-3) → N,N'-bis(4-methoxyphenyl)urea (1227-44-7)

Guidance literature:

In toluene; at 20 ℃; for 5h;

upstream raw materials:

phosgene

4-methoxy-aniline

carbon oxide sulfide

bis(2-methoxy-phenyl)carbonate

Downstream raw materials:

methylene chloride

4-amino-phenol

methylammonium carbonate

4-methoxy-aniline

Refernces

• 1、 Thomson,Wilson. "-". . . Retrieved 1935.
• 2、 Xu, Jun,Sharma, Nandini,Sharma, Upendra K.,Li, Zhenghua,Song, Gonghua,Van Der Eycken, Erik V.. "Cationic Rhodium(III)-Catalyzed Direct C-2 Carboxamidation of Indoles with Isocyanates via C-H Bond Functionalization". . p. 2615 - 2621. Retrieved 2015.
• 3、 Ge,Miller,Ouimet,Smith. "Electrochemically controlled hydrogen bonding. O-quinones as simple redox-dependent receptors for arylureas". . p. 8831 - 8838. Retrieved 2000.
• 4、 Taily, Irshad Maajid,Saha, Debarshi,Banerjee, Prabal. "[3+3] Annulation via Ring Opening/Cyclization of Donor–Acceptor Cyclopropanes with (Un)symmetrical Ureas: A Quick Access to Highly Functionalized Tetrahydropyrimidinones". . p. 7804 - 7813. Retrieved 2019.
• 5、 Jin, Yi,Liu, Xiaoyu,Song, Xizhong,Yu, Wei. "Amide-assisted rearrangement of hydroxyarylformimidoyl chloride to diarylurea". supporting information. . Retrieved 2021/11/11.
• 6、 Chen, Ling,Dong, Yibo,Wu, Yangjie,Yang, Jinchen,Zhang, Jinli. "Di-tert-butyl peroxide (DTBP)-mediated synthesis of symmetrical N,N′-disubstituted urea/thiourea motifs from isothiocyanates in water". supporting information. . Retrieved 2021/12/01.