Demecycline

Base Information

• Chemical Name: Demecycline
• CAS No.: 987-02-0
• Molecular Formula: C21H22 N2 O8
• Molecular Weight: 430.414
• Mol file: 987-02-0.mol

Synonyms:2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-(6CI,8CI); 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,[4S-(4a,4aa,5aa,6b,12aa)]-; 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide;CL 22415; Demecycline; Demethyltetracycline; Floricina

Chemical Property of Demecycline

Chemical Property:

• Vapor Pressure: 3.43E-20mmHg at 25°C
• Boiling Point: 693.5°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 373.2°C
• PSA: 182.61000
• Density: 1.69g/cm³
• LogP: 0.76120
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: Aqueous Acid (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Demethyltetracycline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Demethyltetracycline is a Chlortetracycline(C426500) metabolite, an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial. Demethyltetracycline is a Chlortetracycline (C426500) metabolite, an antibiotic substance isolated from the substrate of Streptomyces aureofaciens. Chlortetracycline is an antimicrobial and antibacterial.

Technology Process of Demecycline

There total 2 articles about Demecycline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Demeclocycline (127-33-3) → 6-demethyltetracycline (987-02-0)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; urea; In water; at 25 - 45 ℃; for 4.16667h; under 3000.3 - 4500.45 Torr; Temperature; Pressure; Reagent/catalyst;

Reference yield: 84.77%

demeclocycline hydrochloride (64-73-3,179471-95-5) → 6-demethyltetracycline (987-02-0)

Guidance literature:

demeclocycline hydrochloride; With ammonium hydroxide; urea; In water; at 25 ℃; for 0.166667h; pH=8;

With palladium 10% on activated carbon; hydrogen; In water; at 35 - 40 ℃; for 6h; under 7500.75 Torr; Pressure; Temperature; pH-value;

Reference yield: 90.7%

6-demethyltetracycline (987-02-0) → sancycline (808-26-4,2696-12-0,15964-02-0,39105-46-9)

Guidance literature:

With methanesulfonic acid; 5%-palladium/activated carbon; hydrogen; In methanol; N,N-dimethyl-formamide; at 30 - 35 ℃; for 5h; under 3000.3 - 6000.6 Torr; Solvent; Temperature; Reagent/catalyst;

upstream raw materials:

demeclocycline hydrochloride

Demeclocycline

Downstream raw materials:

(4aS)-4t-dimethylamino-3,6t,10,12,12a-pentahydroxy-1,11-dioxo-(4ar,5ac,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

MINOCYCLINE

sancycline

Refernces

• 1、 -. "Preparation method 6 - demethyl -6 - dewatered tetracycline (by machine translation)". Paragraph 0013; 0016; 0018; 0020. . Retrieved 2020/09/09.
• 2、 -. "Preparation method of minocycline hydrochloride". Paragraph 0056; 0061; 0069; 0076; 0091; 0098. . Retrieved 2017/08/30.