1-Piperidinoanthraquinone

Base Information

• Chemical Name: 1-Piperidinoanthraquinone
• CAS No.: 4946-83-2
• Molecular Formula: C₁₉H₁₇NO₂
• Molecular Weight: 291.349
• NSC Number: 43586
• UNII: JT7F2L3X6R
• DSSTox Substance ID: DTXSID90197796
• Nikkaji Number: J1.023.330E,J1.375.866B
• Wikidata: Q83070557
• Mol file: 4946-83-2.mol

Synonyms:1-piperidinoanthraquinone

Chemical Property of 1-Piperidinoanthraquinone

Chemical Property:

• Vapor Pressure: 2.89E-10mmHg at 25°C
• Boiling Point: 503.5°Cat760mmHg
• Flash Point: 236.3°C
• PSA: 37.38000
• Density: 1.259g/cm³
• LogP: 3.51730
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 291.125928785
• Heavy Atom Count: 22
• Complexity: 454

Purity/Quality:

99% ^*data from raw suppliers

1-(1-PIPERIDINYL)ANTHRAQUINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=CC=CC3=C2C(=O)C4=CC=CC=C4C3=O

Technology Process of 1-Piperidinoanthraquinone

There total 4 articles about 1-Piperidinoanthraquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

piperidine (110-89-4) + 1-chloroanthracene-9,10-dione (82-44-0) → 1-piperidinoanthraquinone (4946-83-2)

Guidance literature:

In toluene; at 80 ℃; for 48h;

DOI:10.1016/j.molstruc.2018.07.070

Reference yield:

piperidine (110-89-4) + 9,10-phenanthrenequinone (84-65-1) → 1-piperidinoanthraquinone (4946-83-2)

Guidance literature:

With oxygen; {RhCl(PPh₃)₂}₂; at 110 ℃; for 33h; Yield given;

DOI:10.1039/c39800001036

Reference yield:

piperidine (110-89-4) + 1-nitroanthraquinone (82-34-8) → 1-piperidinoanthraquinone (4946-83-2)

Guidance literature:

upstream raw materials:

piperidine

1-nitroanthraquinone

1-chloroanthracene-9,10-dione

9,10-phenanthrenequinone

Downstream raw materials:

9-acetoxy-8-phenylazo-1,3,4,14a-tetrahydro-2H-anthra[1,9-de]pyrido[2,1-b][1,3]oxazine

9-acetoxy-8-(4-nitro-phenylazo)-1,3,4,14a-tetrahydro-2H-anthra[1,9-de]pyrido[2,1-b][1,3]oxazine

9-acetoxy-8-(2,5-dichloro-phenylazo)-1,3,4,14a-tetrahydro-2H-anthra[1,9-de]pyrido[2,1-b][1,3]oxazine

9-benzoyloxy-8-(4-nitro-phenylazo)-1,3,4,14a-tetrahydro-2H-anthra[1,9-de]pyrido[2,1-b][1,3]oxazine

Refernces

• 1、 Niedzia?kowski, Pawe?,Czaczyk, El?bieta,Jarosz, Joanna,Wcis?o, Anna,Bia?obrzeska, Wioleta,Wietrzyk, Joanna,Ossowski, Tadeusz. "Synthesis and electrochemical, spectral, and biological evaluation of novel 9,10-anthraquinone derivatives containing piperidine unit as potent antiproliferative agents". . p. 488 - 495. Retrieved 2019.
• 2、 Arai, Sadao,Kato, Seijiro,Hida, Mitsuhiko. "Amide Ion Formation and N-Alkylation of Aminoanthraquinones in the presence of Potassium Hydroxide in Dimethyl Sulfoxide". . p. 1458 - 1463. Retrieved 2007/10/02.