Hydron;1,3-thiazol-2-amine;chloride

Base Information

• Chemical Name: Hydron;1,3-thiazol-2-amine;chloride
• CAS No.: 6142-05-8
• Molecular Formula: C3H4 N2 S . Cl H
• Molecular Weight: 136.605
• Hs Code.: 2934100090
• Mol file: 6142-05-8.mol

Synonyms:AKOS015898753

Chemical Property of Hydron;1,3-thiazol-2-amine;chloride

Chemical Property:

• Vapor Pressure: 0.14mmHg at 25°C
• Melting Point: 62-63 °C
• Boiling Point: 216.4°C at 760 mmHg
• Flash Point: 84.7°C
• PSA: 67.15000
• LogP: 2.10850
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 135.9861970
• Heavy Atom Count: 7
• Complexity: 48.1

Purity/Quality:

99%, ^*data from raw suppliers

Thiazol-2-aminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].C1=CSC(=N1)N.[Cl-]
• Use Description: **2-Aminothiazole hydrochloride** is a compound with diverse applications across different fields. In the pharmaceutical industry, it serves as a key intermediate in the synthesis of various drugs, particularly antifungal and antibacterial agents. Its presence in these drugs contributes to their efficacy in combating infections. In the field of agriculture, 2-aminothiazole hydrochloride is used as a chemical building block for the development of pesticides and herbicides, helping to protect crops from pests and weeds. Additionally, it finds utility in the realm of chemical research as a reagent for the synthesis of other complex organic compounds. Its versatility and role as a precursor in these various applications make it an important chemical in both scientific research and industrial production.

Technology Process of Hydron;1,3-thiazol-2-amine;chloride

There total 1 articles about Hydron;1,3-thiazol-2-amine;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ aminothiazole hydrochloric acid (6142-05-8)

Guidance literature:

With nitrogen;

Reference yield: 82.0%

aminothiazole hydrochloric acid (6142-05-8) → N-(thiazol-2-yl)formamide (25602-39-5)

Guidance literature:

With sodium formate; acetic anhydride; In water; benzene;

Reference yield: 65.0%

(R)-2-(4-methanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid (745053-46-7) + aminothiazole hydrochloric acid (6142-05-8) → (2R)-3-(tetrahydropyran-4-yl)-2-(4-methanesulfonylphenyl)-N-thiazol-2-ylpropionamide (745051-60-9)

Guidance literature:

(R)-2-(4-methanesulfonylphenyl)-3-(tetrahydropyran-4-yl)propionic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at -20 ℃; for 1h;

With 2,3,5-trimethyl-pyridine; In dichloromethane; for 0.25h;

aminothiazole hydrochloric acid; In dichloromethane; at -15 - 20 ℃; for 4h;

DOI:10.1021/jm8003202

Downstream raw materials:

N-(thiazol-2-yl)thiourea

4-(thiazol-2-ylcarbamoyl)butaric acid

N-(thiazol-2-yl)formamide

8-indan-5-yl-5-oxo-2-[4-(2-pyrrolidin-1-yl-ethyl)-phenylamino]-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid thiazol-2-ylamide

Refernces