N-(benzyl)-2-aminopyrimidine

Base Information

• Chemical Name: N-(benzyl)-2-aminopyrimidine
• CAS No.: 4214-59-9
• Molecular Formula: C11H11N3
• Molecular Weight: 185.228
• Hs Code.: 2933599090
• Mol file: 4214-59-9.mol

Synonyms:benzyl-pyrimidin-2-yl-amine;2-Benzylaminopyrimidine;2-Pyrimidinamine,N-(phenylmethyl);N-(benzyl)-2-aminopyrimidine;N-benzyl-(2-pyrimidyl)amine;

Chemical Property of N-(benzyl)-2-aminopyrimidine

Chemical Property:

• Vapor Pressure: 1.95E-05mmHg at 25°C
• Boiling Point: 362.3°C at 760 mmHg
• Flash Point: 172.9°C
• PSA: 37.81000
• Density: 1.187g/cm³
• LogP: 2.16170

Purity/Quality:

95% ^*data from raw suppliers

n-benzylpyrimidin-2-amine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Benzylpyrimidin-2-amine is used in the preparation of oxalic acid monoamide ligand compounds for catalysis of coupling reactions.

Technology Process of N-(benzyl)-2-aminopyrimidine

There total 21 articles about N-(benzyl)-2-aminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-aminopyrimidine (109-12-6) + benzyl alcohol (100-51-6,185532-71-2) → 2-(benzylamino)pyrimidine (4214-59-9)

Guidance literature:

With iron(II,III) oxide; potassium tert-butylate; In 1,4-dioxane; at 90 ℃; for 168h; Inert atmosphere;

DOI:10.1039/b901929d

Reference yield: 98.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + benzylamine (100-46-9) → 2-(benzylamino)pyrimidine (4214-59-9)

Guidance literature:

With cesium acetate; copper; In dimethyl sulfoxide; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201000708

Reference yield: 97.0%

2-bromopyrimidine (4595-60-2) + benzylamine (100-46-9) → 2-(benzylamino)pyrimidine (4214-59-9)

Guidance literature:

at 100 ℃; for 0.025h; microwave irradiation;

DOI:10.1016/S0040-4020(01)01182-6

upstream raw materials:

2-aminopyrimidine

benzyl chloride

benzyl alcohol

2-chloropyrimidine

Downstream raw materials:

1-acetyl-3-benzyl-1-tert-butyl-3-pyrimidin-2-yl-urea

2-(N-benzylamino)pyrimidine-5-carbaldehyde

Br^(1-)*C₁₉H₁₇IN₃O⁽¹⁺⁾

2-(4-chlorophenyl)-2-hydroxy-1-benzyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

Refernces

• 1、 Nasresfahani, Zahra,Kassaee, Mohamad Z.. "Nickel?Copper bimetallic mesoporous nanoparticles: As an efficient heterogeneous catalyst for N-alkylation of amines with alcohols". . . Retrieved 2020/10/30.
• 2、 Song, Yan-Ling,Li, Bei,Xie, Zhen-Biao,Wang, Dan,Sun, Hong-Mei. "Iron-Catalyzed Oxidative Amination of Benzylic C(sp3)–H Bonds with Anilines". . p. 17975 - 17985. Retrieved 2021/12/13.