N-Ethylacetamide

Base Information

• Chemical Name: N-Ethylacetamide
• CAS No.: 625-50-3
• Molecular Formula: C4H9NO
• Molecular Weight: 87.1216
• Hs Code.: 29241990
• European Community (EC) Number: 210-896-7
• NSC Number: 406307
• UNII: M9Y95ZE6J9
• DSSTox Substance ID: DTXSID5060803
• Nikkaji Number: J26.738D
• Wikidata: Q27159564
• Metabolomics Workbench ID: 44757
• Mol file: 625-50-3.mol

Synonyms:N-ethylacetamide

Chemical Property of N-Ethylacetamide

Chemical Property:

• Appearance/Colour: water white oily liquid.
• Vapor Pressure: 0.256mmHg at 25°C
• Melting Point: -32ºC
• Refractive Index: n20/D 1.433(lit.)
• Boiling Point: 205 ºC at 760 mmHg
• PKA: 16.62±0.46(Predicted)
• Flash Point: 105.4 ºC
• PSA: 29.10000
• Density: 0.866 g/cm³
• LogP: 0.53330
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Fully misicible in water.
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 87.068413911
• Heavy Atom Count: 6
• Complexity: 51.5

Purity/Quality:

NLT 99.0% ^*data from raw suppliers

N-Ethylacetamide >99.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Solvents -> Amides (
• Canonical SMILES: CCNC(=O)C
• Uses: N-ethylacetamide is a suitable nylon model for mechanistic studies of dye fading. N-Ethylacetamide was used to investigate propylene carbonate and a mixture of N-methylformamide and N-ethylacetamide by broadband dielectric and mechanical shear spectroscopy. It was used in determination of reaction products of OH-oxidation of N-methylpyrrolidone under atmospheric conditions. N-Ethylacetamide was used to investigate propylene carbonate and a mixture of N-methylformamide and N-ethylacetamide by broadband dielectric and mechanical shear spectroscopy. It was used in determination of reaction products of OH-oxidation of N-methylpyrrolidone under atmospheric conditions.

Technology Process of N-Ethylacetamide

There total 59 articles about N-Ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Trimethyl orthoacetate (1445-45-0) + ethanamine hydrochloride (557-66-4) → N-ethylacetamide (625-50-3)

Guidance literature:

In methanol; at 135 ℃; for 0.25h; Microwave irradiation;

DOI:10.1080/00397911.2015.1096943

Reference yield: 94.0%

ethylamine (75-04-7,85404-22-4) + acetic acid (64-19-7,77671-22-8) → N-ethylacetamide (625-50-3)

Guidance literature:

With ammonium peroxydisulfate; tetrabutylammomium bromide; potassium hydroxide; In water; at 20 ℃; for 3h; Irradiation;

Reference yield: 87.0%

N-chloro-N-ethylacetamide (5014-40-4) → N-((1R,2S,3S,4S)-3-Chloro-bicyclo[2.2.1]hept-2-yl)-N-ethyl-acetamide (78174-15-9) + N-((1R,2S,3R,4S)-3-Chloro-bicyclo[2.2.1]hept-2-yl)-N-ethyl-acetamide (78174-15-9) + N-ethylacetamide (625-50-3)

Guidance literature:

With norborn-2-ene; In dichloromethane; at 15 - 20 ℃; Yields of byproduct given; Irradiation;

upstream raw materials:

acetamide

ethyl bromide

ethyl methyl ketone oxime

1-acetoxy-2-(ethyl-acetyl-amino)-ethane

Downstream raw materials:

N-ethyl-diacetamide

N-ethylacetanilide

N-ethyl-N-(p-tolyl)acetamide

Acetanilid

Refernces

• 1、 Kuroki,Kanesaka,Yamada,Imoto. "Reactivities of various amines in the modifications of acetic acid and aspartic acid-101 of lysozyme in the carbodiimide reaction". . p. 4203 - 4207. Retrieved 1987.
• 2、 Ma, Ruonan,Chen, Xueyuan,Xiao, Zhiyin,Natarajan, Mookan,Lu, Chunxin,Jiang, Xiujuan,Zhong, Wei,Liu, Xiaoming. "Beckmann rearrangement of ketoximes promoted by cyanuric chloride and dimethyl sulfoxide under a mild condition". supporting information. . Retrieved 2021/01/06.
• 3、 Lin, Yang,Zhu, De-Ping,Du, Yi-Ran,Zhang, Rui,Zhang, Suo-Jiang,Xu, Bao-Hua. "Tris(pyrazolyl)borate Cobalt-Catalyzed Hydrogenation of C=O, C=C, and C=N Bonds: An Assistant Role of a Lewis Base". supporting information. p. 2693 - 2698. Retrieved 2019/04/25.