2-ethyl-1-(4-methoxyphenyl)butan-1-one

Base Information

• Chemical Name: 2-ethyl-1-(4-methoxyphenyl)butan-1-one
• CAS No.: 84836-32-8
• Molecular Formula: C13H18 O2
• Molecular Weight: 206.28
• Hs Code.: 2914509090
• Mol file: 84836-32-8.mol

Synonyms:Butyrophenone,2-ethyl-4'-methoxy- (6CI); NSC 57535

Chemical Property of 2-ethyl-1-(4-methoxyphenyl)butan-1-one

Chemical Property:

• Vapor Pressure: 0.000485mmHg at 25°C
• Boiling Point: 313.8°C at 760 mmHg
• Flash Point: 130.2°C
• PSA: 26.30000
• Density: 0.975g/cm³
• LogP: 3.31410

Purity/Quality:

99% ^*data from raw suppliers

2-ethyl-1-(4-methoxyphenyl)butan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ethyl-1-(4-methoxyphenyl)butan-1-one

There total 6 articles about 2-ethyl-1-(4-methoxyphenyl)butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-Ethylbutyraldehyde (97-96-1) + 4-methoxyphenylboronic acid (5720-07-0) → 2-Ethyl-1-(4-methoxy-phenyl)-butan-1-one (84836-32-8)

Guidance literature:

With 3,3-dimethyl-butan-2-one; dichlorotricarbonylruthenium(II) dimer; potassium phosphate tribasic trihydrate; tri tert-butylphosphoniumtetrafluoroborate; In water; toluene; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c1cc12843d

Reference yield: 82.0%

diethyl malonic acid (510-20-3) + methoxybenzene (100-66-3) → 2-Ethyl-1-(4-methoxy-phenyl)-butan-1-one (84836-32-8)

Guidance literature:

With PPA; at 60 - 80 ℃; for 2h;

DOI:10.1080/00304949909458327

Reference yield: 44.0%

2-Ethylbutanoic acid (88-09-5) + methoxybenzene (100-66-3) → 2-Ethyl-1-(4-methoxy-phenyl)-butan-1-one (84836-32-8)

Guidance literature:

With dysprosium(III) trifluoromethanesulfonate; In toluene; for 48h; Heating / reflux;

upstream raw materials:

2-Ethylbutanoic acid

methoxybenzene

chlorure d'acide ethyl-2 butyrique

diethyl malonic acid

Downstream raw materials:

2-ethyl-1-(4-methoxyphenyl)but-1-enyl t-butyldimethylsilyl ether

(E)-2-ethyl-1-(4-methoxyphenyl)-2-buten-1-one

4-[2-Ethyl-1-(4-fluoro-phenyl)-but-1-enyl]-phenol

2-ethyl-1-(4-hydroxy-phenyl)-butan-1-one

Refernces

• 1、 Li, Hong,Xu, Yuan,Shi, Erbo,Wei, Wei,Suo, Xiangqiang,Wan, Xiaobing. "Synthesis of arylketones by ruthenium-catalyzed cross-coupling of aldehydes with arylboronic acids". supporting information; experimental part. p. 7880 - 7882. Retrieved 2011/08/06.
• 2、 Renault, Olivier,Dallemagne, Patrick,Rault, Sylvain. "Friedel-Crafts acylation with malonic acids in polyphosphoric acid". . p. 324 - 328. Retrieved 2007/10/03.