4-Chlorobenzoylformic acid

Base Information

• Chemical Name: 4-Chlorobenzoylformic acid
• CAS No.: 7099-88-9
• Molecular Formula: C8H5ClO3
• Molecular Weight: 184.579
• Hs Code.: 2918300090
• Mol file: 7099-88-9.mol

Synonyms:Glyoxylicacid, (p-chlorophenyl)- (7CI,8CI);4-Chlorobenzoylformic acid;4-Chlorophenylglyoxylic acid;p-Chlorobenzoylformic acid;p-Chlorophenylglyoxylic acid;

Chemical Property of 4-Chlorobenzoylformic acid

Chemical Property:

• Vapor Pressure: 0.000284mmHg at 25°C
• Melting Point: 94.5-95 °C
• Refractive Index: 1.584
• Boiling Point: 309 °C at 760 mmHg
• PKA: 2.03±0.54(Predicted)
• Flash Point: 140.7 °C
• PSA: 54.37000
• Density: 1.447 g/cm³
• LogP: 1.60730
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% purity ^*data from raw suppliers

2-(4-Chlorophenyl)-2-oxoaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chlorobenzoylformic acid

There total 32 articles about 4-Chlorobenzoylformic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 2-(4-chlorophenyl)-2-oxoacetate (34966-48-8) → 4-chlorophenylglyoxylic acid (7099-88-9)

Guidance literature:

With water; sodium hydroxide; at 20 ℃; for 2h;

DOI:10.1021/ol501479t

Reference yield: 97.0%

1-(4-chlorophenyl)-2-nitroethanol (89979-04-4) → 4-chlorophenylglyoxylic acid (7099-88-9)

Guidance literature:

With copper(II) sulfate; In methanol; water; acetic acid; for 3h; Heating;

DOI:10.1016/S0040-4039(99)02179-6

Reference yield: 96.4%

p-chloro-2-(hydroxyimino)-2-phenylacetonitrile (4236-13-9) → 4-chlorophenylglyoxylic acid (7099-88-9)

Guidance literature:

With sulfuric acid; at 100 ℃; for 8h;

upstream raw materials:

1-(4-Dimethylaminophenylimino-)-2-keto-2-(4-chlorphenyl-)-propionitril

N-[1-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2,3-dioxo-1-phenyl-propyl]-N-methoxy-benzamide

sodium methylate

para-chloroacetophenone

Downstream raw materials:

ethyl 2-(4-chlorophenyl)-2-oxoacetate

2-hydroxy-2-(4-chlorophenyl)propanoic acid

carbonic-acid

4-chlorobenzaldehyde

Refernces

• 1、 Sun, Bin,Shi, Rongcheng,Zhang, Kesheng,Tang, Xiaoli,Shi, Xiayue,Xu, Jiayun,Yang, Jin,Jin, Can. "Photoinduced homolytic decarboxylative acylation/cyclization of unactivated alkenes with α-keto acid under external oxidant and photocatalyst free conditions: access to quinazolinone derivatives". supporting information. p. 6050 - 6053. Retrieved 2021/06/21.
• 2、 Laha, Joydev K.,Panday, Surabhi,Tomar, Monika,Patel, Ketul V.. "Possible competitive modes of decarboxylation in the annulation reactions ofortho-substituted anilines and arylglyoxylates". supporting information. p. 845 - 853. Retrieved 2021/02/09.