3-Hydrazino-6-phenylpyridazine

Base Information

• Chemical Name: 3-Hydrazino-6-phenylpyridazine
• CAS No.: 38956-80-8
• Molecular Formula: C10 H10 N4
• Molecular Weight: 186.216
• Hs Code.: 2933990090
• European Community (EC) Number: 822-631-8
• DSSTox Substance ID: DTXSID50423366
• Nikkaji Number: J868.731E
• Wikidata: Q82235569
• ChEMBL ID: CHEMBL3764140
• Mol file: 38956-80-8.mol

Synonyms:3-hydrazino-6-phenylpyridazine;38956-80-8;3-Hydrazinyl-6-phenylpyridazine;(6-phenylpyridazin-3-yl)hydrazine;MFCD01219682;SCHEMBL1752770;6-Phenyl-3-pyridazinylhydrazine;CHEMBL3764140;DTXSID50423366;ZNGXOKMCRDQBON-UHFFFAOYSA-N;1(6-phenylpyridazin-3-yl)hydrazine;STL573004;1-(6-phenylpyridazin-3-yl)hydrazine;AKOS000266308;BS-3640;3-Hydrazino-6-phenylpyridazine, AldrichCPR;BB 0262983;FT-0717378;EN300-88809;3-hydrazino-6-phenylpyridazine(SALTDATA: FREE);A924541

Chemical Property of 3-Hydrazino-6-phenylpyridazine

Chemical Property:

• Vapor Pressure: 1.3E-08mmHg at 25°C
• Refractive Index: 1.675
• Boiling Point: 459.1ºC at 760 mmHg
• Flash Point: 231.5ºC
• PSA: 63.83000
• Density: 1.259g/cm3
• LogP: 2.20250
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 186.090546336
• Heavy Atom Count: 14
• Complexity: 168

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Hydrazino-6-phenylpyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NN=C(C=C2)NN

Technology Process of 3-Hydrazino-6-phenylpyridazine

There total 7 articles about 3-Hydrazino-6-phenylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-chloro-6-phenylpyradazine (20375-65-9) → 3-hydrazino-6-phenylpyridazine (38956-80-8)

Guidance literature:

With hydrazine; at 130 ℃; for 1h;

DOI:10.1021/jm800043g

Reference yield: 57.0%

→ 3-hydrazino-6-phenylpyridazine (38956-80-8)

Guidance literature:

Reference yield:

6-phenylpyridazin-3(2H)-one (2166-31-6) → 3-hydrazino-6-phenylpyridazine (38956-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus oxychloride / 4 h / 85 - 95 °C

2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C

With hydrazine hydrate; trichlorophosphate; In butan-1-ol;

DOI:10.1021/jm00385a003

upstream raw materials:

3-chloro-6-phenylpyradazine

6-phenylpyridazin-3(2H)-one

6-phenyl-2,3,4,5-tetrahydropyridazin-3-one

succinylbenzene

Downstream raw materials:

6-phenyl-3-(3'-pyridinyl)pyridazino[3,2-c]1,2,4-triazole

N-{2-[3-oxo-2-(6-phenylpyridazin-3-yl)-2,3-dihydro-1H-pyrazol-4-yl]ethyl}benzamide

Refernces

• 1、 -. "CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF". Paragraph 1172. . Retrieved 2018/04/17.
• 2、 Islam, Mojahidul,Siddiqui, Anees A.. "Synthesis, antituberculostatic, antifungal and antibacterial activities of 3-substituted phenyl-6-substituted phenyl-1,2,4-triazolo[4,3-b]pyridazines". experimental part. p. 555 - 562. Retrieved 2011/05/05.