2-METHYL-4-PHENYL-THIAZOLE

Base Information

• Chemical Name: 2-METHYL-4-PHENYL-THIAZOLE
• CAS No.: 1826-16-0
• Molecular Formula: C10H9NS
• Molecular Weight: 175.254
• Hs Code.: 2934100090
• Mol file: 1826-16-0.mol

Synonyms:2-Methyl-4-phenylthiazole;4-Phenyl-2-methyl-1,3-thiazole;

Chemical Property of 2-METHYL-4-PHENYL-THIAZOLE

Chemical Property:

• Vapor Pressure: 0.00274mmHg at 25°C
• Melting Point: 215-216℃
• Refractive Index: 1.593
• Boiling Point: 295.1 °C at 760 mmHg
• Flash Point: 135.9 °C
• PSA: 41.13000
• Density: 1.14 g/cm³
• LogP: 3.11850
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methyl-4-phenylthiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 2-methyl-4-phenyl Thiazole is a synthetic intermediate useful for pharmaceutical synthesis.
• Uses: 2-methyl-4-phenyl Thiazole is a synthetic intermediate useful for pharmaceutical synthesis.[Cayman Chemical]

Technology Process of 2-METHYL-4-PHENYL-THIAZOLE

There total 33 articles about 2-METHYL-4-PHENYL-THIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thioacetamide (62-55-5) + α-bromoacetophenone (70-11-1) → 2-methyl-4-phenylthiazole (1826-16-0)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃; for 1h; Sealed tube;

DOI:10.1016/j.tet.2013.10.053

Reference yield: 91.0%

1-phenyl-2-(p-tolylsulfonyloxy)ethanone (7257-94-5) + thioacetamide (62-55-5) → 2-methyl-4-phenylthiazole (1826-16-0)

Guidance literature:

With β‐cyclodextrin; In water; acetone; at 20 ℃; for 2h;

DOI:10.1080/00397910701575913

Reference yield: 88.0%

thioacetamide (62-55-5) + phenylacetylene (536-74-3) → 2-methyl-4-phenylthiazole (1826-16-0)

Guidance literature:

With chloro-[1,2-bis(diphenylphosphino)-1,2-dicarba-closo-dodecaborane-κ²P,P’]gold(I); In toluene; at 20 ℃; for 3h; Reagent/catalyst; Solvent; Time;

upstream raw materials:

thioacetamide

α-bromoacetophenone

2-mercaptoacetophenone

acetonitrile

Downstream raw materials:

(3-methyl-4-phenyl-thiazol-2-yl)-(4-methyl-3-phenyl-thiazol-2-yl)-methinium ; iodide

4-phenyl-2-styrylthiazole

2,3-dimethyl-4-phenylthiazolium iodide

2-methyl-4-(4-nitrophenyl)thiazole

Refernces

• 1、 Heravi, Majid M.,Poormohammad, Nargess,Beheshtiha, Yahia S.,Baghernejad, Bita. "Efficient synthesis of 2,4-disubstituted thiazoles under grinding". . p. 579 - 582. Retrieved 2011.
• 2、 Kariofillis, Stavros K.,Shields, Benjamin J.,Tekle-Smith, Makeda A.,Zacuto, Michael J.,Doyle, Abigail G.. "Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source". supporting information. p. 7683 - 7689. Retrieved 2020/04/22.
• 3、 Pollinger, Julius,Schierle, Simone,Neumann, Sebastian,Ohrndorf, Julia,Kaiser, Astrid,Merk, Daniel. "Computer-Assisted Selective Optimization of Side-Activities—from Cinalukast to a PPARα Modulator". supporting information. p. 1343 - 1348. Retrieved 2019/07/04.