4-phenylbicyclo[2.2.2]octan-1-ol

Base Information

• Chemical Name: 4-phenylbicyclo[2.2.2]octan-1-ol
• CAS No.: 2001-62-9
• Molecular Formula: C14H18 O
• Molecular Weight: 202.296
• Hs Code.: 2906299090
• Mol file: 2001-62-9.mol

Synonyms:1-Hydroxy-4-phenylbicyclo[2.2.2]octane;NSC 300597

Chemical Property of 4-phenylbicyclo[2.2.2]octan-1-ol

Chemical Property:

• Vapor Pressure: 0.000172mmHg at 25°C
• Boiling Point: 316.5°Cat760mmHg
• Flash Point: 123.9°C
• PSA: 20.23000
• Density: 1.165g/cm³
• LogP: 3.02330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-phenylbicyclo[2.2.2]octan-1-ol

There total 7 articles about 4-phenylbicyclo[2.2.2]octan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-hydroxy-4-phenylbicyclo<2.2.2>octan-3-one (111143-08-9) → 4-Phenylbicyclo<2.2.2>octan-1-ol (2001-62-9)

Guidance literature:

1-hydroxy-4-phenylbicyclo<2.2.2>octan-3-one; With hydrazine hydrate; for 5h; Heating;

With potassium hydroxide; In diethylene glycol; at 160 - 220 ℃; Further stages.;

DOI:10.1002/chem.200700223

Reference yield:

C16H20OS2 (841-22-5) → 4-Phenylbicyclo<2.2.2>octan-1-ol (2001-62-9)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In diethylene glycol;

DOI:10.1021/ja01077a030

Reference yield:

4-acetyl-4-phenylcyclohexanone (57027-82-4) → 4-Phenylbicyclo<2.2.2>octan-1-ol (2001-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 73 percent / potassium hydroxide / ethanol / 20 °C

2.1: hydrazine hydrate / 5 h / Heating

2.2: 62 percent / potassium hydroxide / bis-(2-hydroxy-ethyl) ether / 160 - 220 °C

With potassium hydroxide; hydrazine hydrate; In ethanol;

DOI:10.1002/chem.200700223

upstream raw materials:

C₁₆H₂₀OS₂

1-hydroxy-4-phenylbicyclo<2.2.2>octan-3-one

4-acetyl-4-phenylcyclohexanone

3-acetyl-3-phenyl-1,5-pentanedicarboxylic acid

Downstream raw materials:

1,4-bis(4-bromophenyl)bicyclo<2.2.2>octane

1-fluoro-4-(4-aminophenyl)bicyclo<2.2.2>octane

1,4-Diphenyl-bicyclo<2.2.2>octane

1-Acetamido-4-phenylbicyclo<2.2.2>octan

Refernces

• 1、 Kopecky, Jan,Smejkal, Jaroslav,Hanus, Vladimir. "SYNTHESIS OF BRIDGEHEAD BICYCLOOCTANOLS". . p. 1370 - 1375. Retrieved 2007/10/02.