2-hydroxyestradiol-2,3-dibenzoate

Base Information

• Chemical Name: 2-hydroxyestradiol-2,3-dibenzoate
• CAS No.: 79787-03-4
• Molecular Formula: C32H32 O5
• Molecular Weight: 0
• Mol file: 79787-03-4.mol

Synonyms:2-Hydroxy-17b-estradiol 3,4-dibenzoate

Chemical Property of 2-hydroxyestradiol-2,3-dibenzoate

Chemical Property:

• Vapor Pressure: 9.19E-19mmHg at 25°C
• Boiling Point: 668.1°C at 760 mmHg
• Flash Point: 218.1°C
• Density: 1.238g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxyestradiol-2,3-dibenzoate

There total 3 articles about 2-hydroxyestradiol-2,3-dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-hydroxyestrone 2,3-dibenzoate (116282-36-1) → 2-hydroxyestradiol 2,3-dibenzoate (79787-03-4)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; for 72h; Ambient temperature;

DOI:10.1016/0039-128X(82)90148-9

Reference yield:

2-hydroxyestrone (362-06-1,4735-38-0) → 2-hydroxyestradiol 2,3-dibenzoate (79787-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / pyridine / 18 h / Ambient temperature

2: 66 percent / NaBH₄ / tetrahydrofuran / 72 h / Ambient temperature

With sodium tetrahydroborate; In tetrahydrofuran; pyridine;

DOI:10.1016/0039-128X(82)90148-9

Reference yield:

benzoyl chloride (98-88-4) → 2-hydroxyestradiol 2,3-dibenzoate (79787-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / pyridine / 18 h / Ambient temperature

2: 66 percent / NaBH₄ / tetrahydrofuran / 72 h / Ambient temperature

With sodium tetrahydroborate; In tetrahydrofuran; pyridine;

DOI:10.1016/0039-128X(82)90148-9

upstream raw materials:

2-hydroxyestrone 2,3-dibenzoate

2-hydroxyestrone

benzoyl chloride

Refernces