TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

Base Information

• Chemical Name: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
• CAS No.: 3685-26-5
• Molecular Formula: C7H12O3
• Molecular Weight: 144.17
• Hs Code.: 2918199090
• Mol file: 3685-26-5.mol

Synonyms:trans-4-Hydroxycyclohexanecarboxylicacid;4-hydroxycyclohexanecarboxylic acid;4-Hydroxycyclohexane carboxylic acid;4-Hydroxycyclohexane-1-carboxylic acid;4-hydroxycyclohexanecarboxylic acid;Cyclohexanecarboxylic acid, 4-hydroxy-;

Chemical Property of TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 145°C
• Refractive Index: 1.523
• Boiling Point: 307.9 °C at 760 mmHg
• PKA: pK1:4.687 (25°C)
• Flash Point: 154.2 °C
• PSA: 57.53000
• Density: 1.246 g/cm³
• LogP: 0.62210
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

trans-4-HydroxycyclohexylcarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: trans-4-Hydroxycyclohexylcarboxylic Acid acts as a reagent in the synthetic preparation of pyrazole-pyrimidine preparation as TTK inhibitors and potential antitumors, Preparation and Janus kinase 1 (JAK1)-selective inhibitory activity of benzimidazole derivatives.

Technology Process of TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID

There total 41 articles about TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-hydroxy-benzoic acid (99-96-7) → 4-hydroxycyclohexanecarboxylic acid (3685-22-1,3685-26-5,17419-81-7)

Guidance literature:

With Rh/Al₂O₃; hydrogen; In methanol; at 20 ℃;

DOI:10.2298/JSC150430063O

Reference yield: 96.0%

ethyl (1s,4s)-4-hydroxycyclohexanecarboxylate (75877-66-6) → cis-4-hydroxycyclohexanecarboxylic acid (3685-26-5,17419-81-7,3685-22-1)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 7h;

DOI:10.1016/j.chempr.2019.03.010

Reference yield: 90.0%

methyl 4-hydroxycyclohexanecarboxylate (3618-03-9,6125-57-1,17449-76-2) → 4-hydroxycyclohexanecarboxylic acid (3685-22-1,3685-26-5,17419-81-7)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; Cooling with ice;

upstream raw materials:

Ethyl 4-hydroxybenzoate

4-oxocyclohexanecarboxylic acid

trans-4-hydroxy-cyclohexane carboxylic acid ethyl ester

4-hydroxy-benzoic acid

Downstream raw materials:

2-chloro-3-(trans-4-hydroxycyclohexyl)-1,4-naphthoquinone

2-chloro-3-(cis-4-hydroxycyclohexyl)-1,4-naphthoquinone

trans-4-Hydroxy-cyclohexanecarboxylic acid hydrazide

butane-1,2,4-tricarboxylic acid

Refernces

• 1、 Ling, Xiujun,Wilcox, Craig S.. "A Molecular Torsion Balance Study: A Nearby Anionic Group Exerts Little Influence on Hydrophobic Interactions between Nonpolar Surfaces". supporting information. p. 14010 - 14014. Retrieved 2019/11/14.
• 2、 -. "DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY". Paragraph 1087; 1088. . Retrieved 2017/02/28.