N-(2-Hydroxyethyl)-2-phenoxyacetamide

Base Information

• Chemical Name: N-(2-Hydroxyethyl)-2-phenoxyacetamide
• CAS No.: 6326-87-0
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2924299090
• European Community (EC) Number: 228-694-2
• NSC Number: 31342
• UNII: FD7R9R62DB
• DSSTox Substance ID: DTXSID70212653
• Nikkaji Number: J206.925C
• Wikidata: Q83087810
• Mol file: 6326-87-0.mol

Synonyms:N-(2-Hydroxyethyl)-2-phenoxyacetamide;6326-87-0;N-(2-Hydroxyethyl)Phenoxyacetamide;FD7R9R62DB;Acetamide, N-(2-hydroxyethyl)-2-phenoxy-;EINECS 228-694-2;NSC-31342;NSC31342;UNII-FD7R9R62DB;DTXSID70212653;NSC 31342;AKOS008930152;Acetamide,N-(2-hydroxyethyl)-2-phenoxy-

Chemical Property of N-(2-Hydroxyethyl)-2-phenoxyacetamide

Chemical Property:

• Vapor Pressure: 1.38E-08mmHg at 25°C
• Refractive Index: 1.537
• Boiling Point: 441.9 °C at 760 mmHg
• Flash Point: 221.1 °C
• PSA: 58.56000
• Density: 1.173 g/cm³
• LogP: 0.56480
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

99% ^*data from raw suppliers

N-(2-HYDROXYETHYL)PHENOXYACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OCC(=O)NCCO

Technology Process of N-(2-Hydroxyethyl)-2-phenoxyacetamide

There total 2 articles about N-(2-Hydroxyethyl)-2-phenoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethanolamine (141-43-5) + 2-phenoxyacetic acid (122-59-8) → N-(2-hydroxyethyl)-2-phenoxyacetamide (6326-87-0)

Guidance literature:

With tris(2,6-dimethoxyphenyl)bismuthane; In benzene; for 12h; Heating;

DOI:10.1246/cl.1993.815

Reference yield:

phenoxyacetic acid ethyl ester (2555-49-9) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)-2-phenoxyacetamide (6326-87-0)

Guidance literature:

DOI:10.1021/ja01189a003

Reference yield: 80.0%

N-(2-hydroxyethyl)-2-phenoxyacetamide (6326-87-0) + (7bS,4S,5aR,7aR)-4-methyl-2-oxo-4,5,5a,6,7,7a-hexahydroindeno[1,7-bc]furan-7b(2H)-yl acetate → N-(2-(((7bS,4S,5aR,7aR)-4-methyl-2-oxo-4,5,5a,6,7,7a-hexahydroindeno[1,7-bc]furan-7b(2H)-yl)oxy)ethyl)-2-phenoxyacetamide

Guidance literature:

With dmap; In chloroform-d1; at 20 ℃; for 2h;

DOI:10.1021/acs.joc.0c00152

upstream raw materials:

phenoxyacetic acid ethyl ester

ethanolamine

2-phenoxyacetic acid

Downstream raw materials:

4,5-dihydro-2-(phenoxymethyl)-1,3-thiazole

N-(2-chloro-ethyl)-2-phenoxy-acetamide

2-Anilinoethanol

2-phenoxymethyl-4,5-dihydro-oxazole

Refernces

• 1、 Ogawa, Takuji,Hikasa, Tetsuya,Ikegami, Tohru,Ono, Noboru,Suzuki, Hitomi. "Electron-rich Triarylbismuthines as Selective Condensation Reagent under Neutral Conditions. Condensation of Aliphatic Carboxylic Acids with Amines and Alcohols". . p. 815 - 818. Retrieved 2007/10/02.