bicyclo[2.2.2]octan-7-ol

Base Information

• Chemical Name: bicyclo[2.2.2]octan-7-ol
• CAS No.: 18684-63-4
• Molecular Formula: C8H14O
• Molecular Weight: 126.199
• Hs Code.: 2906199090
• Mol file: 18684-63-4.mol

Synonyms:2-bicyclo<2.2.2>octanol;(+/-)-Bicyclo<2.2.1>octan-2-ol;(+-)-2-Hydroxy-bicyclo[2.2.2]octan;Bicyclo[2.2.2]octan-2-ol;BICYCLO[2.2.2]OCTAN-7-OL;

Chemical Property of bicyclo[2.2.2]octan-7-ol

Chemical Property:

• Vapor Pressure: 0.0459mmHg at 25°C
• Melting Point: 216-217 °C
• Boiling Point: 209.7°C at 760 mmHg
• PKA: 15.12±0.20(Predicted)
• Flash Point: 84°C
• PSA: 20.23000
• Density: 1.052g/cm³
• LogP: 1.55740
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Bicyclo[2.2.2]octan-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of bicyclo[2.2.2]octan-7-ol

There total 40 articles about bicyclo[2.2.2]octan-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

bicyclo[2.2.2]oct-5-en-2-one (2220-40-8) → bicyclo[2.2.2]octan-2-ol (18684-63-4)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 20 ℃; for 1h; under 1551.49 Torr;

Reference yield: 70.0%

norbornene (931-64-6) → bicyclo[2.2.2]octan-2-ol (18684-63-4)

Guidance literature:

With dimethylsulfide borane complex; dihydrogen peroxide; In diethyl ether;

DOI:10.1021/jo00346a049

Reference yield: 49.0%

C11H18O3 → bicyclo[2.2.2]octan-2-ol (18684-63-4)

Guidance literature:

With potassium tert-butylate; hydrogen; C₁₆H₁₈BrCoINO₂; In dibutyl ether; at 160 ℃; for 20h; under 45004.5 Torr; Sealed tube; Autoclave;

DOI:10.1002/cctc.202001490

upstream raw materials:

acetic acid bicyclo[2.2.2]oct-2-yl ester

2,3-epoxybicyclo<2.2.2>oct-2-ene

bicyclo[2,2,2]octane

norbornene

Downstream raw materials:

bicyclo[2.2.2]octan-2-one

2-chloro-bicyclo[2.2.2]octane

4-bromo-benzenesulfonic acid bicyclo[2.2.2]oct-2-yl ester

Bicyclo<2.2.2>octan-2-one

Refernces

• 1、 Lambert, Joseph B.,Liu, Xiaoyang. "The β-effect of silicon in the orthogonal geometry". . p. 203 - 210. Retrieved 1996.
• 2、 -. "NOVEL FUSED BRIDGED BICYCLIC HETEROARYL SUBSTITUTED 6-ALKYLIDENE PENEMS AS POTENT BETA-LACTAMASE INHIBITORS". . . Retrieved 2011/12/12.
• 3、 -. "Bicyclic hexahydroaporphine and 1-benzyloctahydroisoquinoline therapeutic compositions and processes for utilizing said compositions". . . Retrieved 2008/06/13.