4-aminobenzylcarazolol

Base Information

• Chemical Name: 4-aminobenzylcarazolol
• CAS No.: 82408-63-7
• Molecular Formula: C₂₅H₂₉N₃O₂
• Molecular Weight: 403.524
• Mol file: 82408-63-7.mol

Synonyms:

Chemical Property of 4-aminobenzylcarazolol

Chemical Property:

• Vapor Pressure: 1.1E-18mmHg at 25°C
• Boiling Point: 666.7°C at 760 mmHg
• Flash Point: 357°C
• PSA: 72.30000
• Density: 1.227g/cm³
• LogP: 5.83760

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-aminobenzylcarazolol

There total 2 articles about 4-aminobenzylcarazolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(+/-)-15-(4-nitrobenzyl)carazolol (82408-66-0) → (+/-)-15-(4-aminobenzyl)carazolol (97458-55-4,82408-63-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 1.5h; under 2844.3 Torr;

DOI:10.1021/jm00360a009

Reference yield:

4-(2,3-epoxypropoxy)carbazole (51997-51-4,95093-96-2) → (+/-)-15-(4-aminobenzyl)carazolol (97458-55-4,82408-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / ethanol / 72 h / 65 °C

2: 82 percent / conc. HCl, H₂ / 5percent Pd/C / methanol / 1.5 h / 2844.3 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; ethanol;

DOI:10.1021/jm00360a009

Reference yield:

(+/-)-15-(4-aminobenzyl)carazolol (97458-55-4,82408-63-7) → C25H28(125)IN3O2 (82408-67-1) + C25H28(125)IN3O2 (85135-41-7) + C25H27(125)I2N3O2 (85135-43-9)

Guidance literature:

With sodium hydroxide; sodium (12?I)iodide; chloroamine-T; for 0.0166667h; Yield given. Yields of byproduct given; Ambient temperature; sodium acetate buffer pH 5.6;

DOI:10.1021/jm00360a009

upstream raw materials:

(+/-)-15-(4-nitrobenzyl)carazolol

4-(2,3-epoxypropoxy)carbazole

Downstream raw materials:

C₂₅H₂₈⁽¹²⁵⁾IN₃O₂

C₂₅H₂₈⁽¹²⁵⁾IN₃O₂

C₂₅H₂₇⁽¹²⁵⁾I₂N₃O₂

Refernces